Detailed information of TA system TA024762

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 251269..251834
• Replicon: chromosome
• Accession: NC_014158
• Organism: Tsukamurella paurometabola DSM 20162

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: TPAU_RS01195
• Protein ID: WP_174234857.1
• Coordinates: 251580..251834 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D5UQQ5
• Locus tag: TPAU_RS01190
• Protein ID: WP_013124943.1
• Coordinates: 251269..251544 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TPAU_RS01180	248791..249426	+	636	WP_013124941.1	aspartyl-tRNA amidotransferase subunit B	-
TPAU_RS01185	249520..250155	+	636	WP_013124942.1	aspartyl-tRNA amidotransferase subunit B	-
TPAU_RS22795	250205..250489	+	285	WP_147291130.1	hypothetical protein	-
TPAU_RS01190	251269..251544	+	276	WP_013124943.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
TPAU_RS01195	251580..251834	+	255	WP_174234857.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
TPAU_RS01200	252079..252414	+	336	WP_013124945.1	Lsr2 family protein	-
TPAU_RS01205	252710..252943	+	234	WP_013124947.1	hypothetical protein	-
TPAU_RS01215	253245..253424	-	180	WP_013124948.1	antitoxin	-
TPAU_RS01220	253736..255547	-	1812	WP_041944217.1	ABC transporter permease	-
TPAU_RS01225	255666..256472	-	807	WP_049825737.1	ATP-binding cassette domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-81)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-70)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9626.12 Da
• Isoelectric Point: 11.8995

>T24762 WP_174234857.1 NC_014158:251580-251834 [Tsukamurella paurometabola DSM 20162]
IAAGPAARRALRRLPTKVAAAIVEFITGPLADNPHRLSKPLRNEYDGYRSARRGDYRVLLRVDNSTRRVLIIDIDHRAHI
YRPR

Nucleotide

• Length: 255 bp

>T24762 NC_014158:251580-251834 [Tsukamurella paurometabola DSM 20162]
ATAGCTGCCGGCCCGGCAGCCCGTCGCGCCCTACGCCGACTACCGACCAAGGTCGCCGCAGCGATCGTAGAGTTCATCAC
CGGCCCACTCGCGGACAATCCGCACCGGCTCAGCAAACCGCTGCGCAACGAATACGACGGCTACCGCAGCGCCCGCCGCG
GCGACTACCGCGTCCTGCTACGCGTCGATAACAGCACTCGAAGGGTGCTCATCATCGACATCGATCACCGTGCACACATC
TACCGACCTCGGTAG

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 9537.59 Da
• Isoelectric Point: 4.4193

>AT24762 WP_013124943.1 NC_014158:251269-251544 [Tsukamurella paurometabola DSM 20162]
MTTVPLGEAKDRLSALVDSAESTHDIITITRHGRAAAVLMSADDLESMQETIFWLSRPGTAAAIAEAEHDAAAGTASSGN
DLRAEFGLTPR

Nucleotide

• Length: 276 bp

>AT24762 NC_014158:251269-251544 [Tsukamurella paurometabola DSM 20162]
ATGACGACCGTGCCGCTCGGCGAAGCCAAGGACCGCCTGTCCGCGCTGGTCGACAGTGCGGAATCGACCCATGACATCAT
CACCATCACCCGACACGGCCGCGCGGCCGCGGTGCTGATGTCCGCCGATGATCTGGAGTCGATGCAGGAGACGATCTTCT
GGCTCTCGCGCCCCGGCACAGCCGCCGCGATCGCCGAAGCCGAACACGACGCCGCTGCCGGCACCGCCAGCTCCGGAAAC
GACCTGCGGGCCGAGTTCGGCCTAACGCCGCGGTGA

Structures

Antitoxin

• AlphaFold DB: D5UQQ5