Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 880100..880760 Replicon chromosome
Accession NZ_CP098438
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ATOMSal-L6

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag M9193_RS04230 Protein ID WP_000244756.1
Coordinates 880347..880760 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag M9193_RS04225 Protein ID WP_000351186.1
Coordinates 880100..880366 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9193_RS04205 (876028) 876028..877461 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
M9193_RS04210 (877620) 877620..877931 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
M9193_RS04215 (878095) 878095..878754 + 660 WP_000250289.1 hemolysin III family protein -
M9193_RS04220 (878870) 878870..879850 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
M9193_RS04225 (880100) 880100..880366 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
M9193_RS04230 (880347) 880347..880760 + 414 WP_000244756.1 protein YgfX Toxin
M9193_RS04235 (880813) 880813..881334 - 522 WP_001055885.1 flavodoxin FldB -
M9193_RS04240 (881447) 881447..882343 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
M9193_RS04245 (882367) 882367..883080 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M9193_RS04250 (883086) 883086..884819 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T247619 WP_000244756.1 NZ_CP098438:880347-880760 [Salmonella enterica subsp. enterica serovar Typhimurium]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT247619 WP_000351186.1 NZ_CP098438:880100-880366 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References