247614

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 38771..39908 Replicon plasmid pCQ025-3
Accession NZ_CP098421
Organism Enterococcus faecalis strain CQ025

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag NAG09_RS14965 Protein ID WP_250170996.1
Coordinates 38771..39634 (-) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID B3CKC7
Locus tag NAG09_RS14970 Protein ID WP_002333002.1
Coordinates 39636..39908 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAG09_RS14940 (34226) 34226..34570 + 345 Protein_38 IS30 family transposase -
NAG09_RS14945 (34642) 34642..36255 - 1614 WP_002333004.1 hypothetical protein -
NAG09_RS14950 (36279) 36279..37160 - 882 WP_002326774.1 ABC transporter ATP-binding protein -
NAG09_RS14955 (37471) 37471..38067 + 597 WP_085442989.1 TetR/AcrR family transcriptional regulator -
NAG09_RS14960 (38236) 38236..38640 - 405 Protein_42 DnaJ domain-containing protein -
NAG09_RS14965 (38771) 38771..39634 - 864 WP_250170996.1 zeta toxin family protein Toxin
NAG09_RS14970 (39636) 39636..39908 - 273 WP_002333002.1 antitoxin Antitoxin
NAG09_RS14975 (39926) 39926..40141 - 216 WP_001835296.1 peptide-binding protein -
NAG09_RS14980 (40233) 40233..41129 - 897 WP_104681373.1 ParA family protein -
NAG09_RS14985 (41232) 41232..43064 - 1833 WP_250652965.1 type IA DNA topoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid dfrG / aph(3')-III / erm(B) - 1..59669 59669


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-214)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32365.76 Da        Isoelectric Point: 6.3643

>T247614 WP_250170996.1 NZ_CP098421:c39634-38771 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELVQGKKAVESPTAFLLGGQPGSGKTSLRSAIFEETQGNVVVIDNDTFKQQHPNFDELV
KLYEKDVVKHATPYSNRMTEALISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKTYAMAVPKIESYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL

Download         Length: 864 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.29 Da        Isoelectric Point: 7.1987

>AT247614 WP_002333002.1 NZ_CP098421:c39908-39636 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELKAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2Z6BWJ3

References