Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 708388..709015 Replicon chromosome
Accession NC_014152
Organism Thermincola potens JR

Toxin (Protein)


Gene name mazF Uniprot ID D5XCG0
Locus tag THERJR_RS03595 Protein ID WP_013119607.1
Coordinates 708665..709015 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag THERJR_RS03590 Protein ID WP_013119606.1
Coordinates 708388..708663 (+) Length 92 a.a.

Genomic Context

THERJR_RS03570THERJR_RS03575THERJR_RS03580THERJR_RS03585THERJR_RS03590THERJR_RS03595THERJR_RS03600THERJR_RS03605THERJR_RS03610THERJR_RS16730
Location: 704146..705648 (1503 bp)
Type: Others
Protein ID: WP_013119602.1
Location: 705661..706104 (444 bp)
Type: Others
Protein ID: WP_013119603.1
Location: 706128..707393 (1266 bp)
Type: Others
Protein ID: WP_013119604.1
Location: 707389..708135 (747 bp)
Type: Others
Protein ID: WP_041587947.1
Location: 708388..708663 (276 bp)
Type: Antitoxin
Protein ID: WP_013119606.1
Location: 708665..709015 (351 bp)
Type: Toxin
Protein ID: WP_013119607.1
Location: 709183..709911 (729 bp)
Type: Others
Protein ID: WP_013119608.1
Location: 709979..711860 (1882 bp)
Type: Others
Protein ID: Protein_711
Location: 711983..712807 (825 bp)
Type: Others
Protein ID: WP_013119609.1
Location: 713000..713149 (150 bp)
Type: Others
Protein ID: WP_198360516.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
THERJR_RS03570704146..705648+1503WP_013119602.1alpha-hydroxy-acid oxidizing protein-
THERJR_RS03575705661..706104+444WP_013119603.14Fe-4S dicluster domain-containing protein-
THERJR_RS03580706128..707393+1266WP_013119604.1NAD(P)/FAD-dependent oxidoreductase-
THERJR_RS03585707389..708135+747WP_041587947.1hypothetical protein-
THERJR_RS03590708388..708663+276WP_013119606.1ribbon-helix-helix protein, CopG familyAntitoxin
THERJR_RS03595708665..709015+351WP_013119607.1type II toxin-antitoxin system PemK/MazF family toxinToxin
THERJR_RS03600709183..709911+729WP_013119608.1gamma-glutamyl-gamma-aminobutyrate hydrolase family protein-
THERJR_RS03605709979..711860+1882Protein_711RNA-binding transcriptional accessory protein-
THERJR_RS03610711983..712807+825WP_013119609.1hypothetical protein-
THERJR_RS16730713000..713149+150WP_198360516.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-42)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12635.57 Da        Isoelectric Point: 4.6677

>T24761 WP_013119607.1 NC_014152:708665-709015 [Thermincola potens JR]
MLIRRGDIFFADLSPVVGSEQGGTRPVLVLQNDIGNQYSPTTIVAAITSQISKAKLPTHVEISAKNSGLEKDSVILLEQI
RTIDKSRLMEKVTSLSEEDMEKVAQAIEISLGLIDI

Download         Length: 351 bp

>T24761 NC_014152:708665-709015 [Thermincola potens JR]
ATGCTTATCCGACGCGGTGATATCTTCTTTGCAGATTTAAGTCCGGTAGTTGGTTCGGAACAGGGCGGGACGCGACCGGT
TTTAGTACTACAAAACGATATAGGCAATCAATACAGTCCGACCACCATAGTAGCGGCAATCACTTCTCAAATAAGCAAAG
CCAAACTTCCTACTCATGTAGAAATATCTGCAAAAAACAGTGGGTTGGAAAAGGATTCGGTTATTTTGCTGGAACAGATT
CGTACTATTGATAAAAGCCGGTTAATGGAAAAGGTTACATCTTTGAGTGAAGAAGATATGGAAAAGGTAGCTCAAGCTAT
CGAGATCAGCCTAGGGTTAATTGATATTTAG

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10574.37 Da        Isoelectric Point: 9.9603

>AT24761 WP_013119606.1 NC_014152:708388-708663 [Thermincola potens JR]
VAEVKRIMISLPDNLLREVDGIVAAEKLNRSEFIREAMKLYIQEKKRRTIREQMKKGYLEMAKINLALAGENFNVEHEVT
RLFDGRLAEGK

Download         Length: 276 bp

>AT24761 NC_014152:708388-708663 [Thermincola potens JR]
GTGGCGGAAGTAAAAAGAATTATGATTAGTTTACCTGATAACCTGTTGCGCGAAGTAGACGGTATCGTGGCTGCGGAAAA
ACTTAATCGCAGTGAGTTTATTCGTGAGGCCATGAAACTTTATATCCAGGAGAAAAAACGGAGAACTATCAGGGAGCAAA
TGAAGAAAGGATACTTAGAGATGGCCAAAATCAACTTGGCGTTGGCTGGAGAAAATTTTAATGTTGAACATGAAGTCACA
CGCCTTTTTGATGGAAGGTTAGCGGAGGGTAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0L6W2S7

Antitoxin

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Source
ID
Structure
No matching records found

References