Detailed information of TA system TA024760

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 532373..532955
• Replicon: chromosome
• Accession: NC_014152
• Organism: Thermincola potens JR

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: D5XB91
• Locus tag: THERJR_RS02705
• Protein ID: WP_013119434.1
• Coordinates: 532373..532705 (-)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: D5XB92
• Locus tag: THERJR_RS02710
• Protein ID: WP_013119435.1
• Coordinates: 532707..532955 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
THERJR_RS02680	527947..528843	+	897	WP_013119430.1	LysR family transcriptional regulator	-
THERJR_RS02685	528874..529914	-	1041	WP_013119431.1	putative sulfate exporter family transporter	-
THERJR_RS02690	530078..530824	-	747	WP_013119432.1	adenosylcobinamide-GDP ribazoletransferase	-
THERJR_RS02695	531639..531875	-	237	WP_157723909.1	hypothetical protein	-
THERJR_RS02700	531906..532256	-	351	WP_157723910.1	hypothetical protein	-
THERJR_RS02705	532373..532705	-	333	WP_013119434.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
THERJR_RS02710	532707..532955	-	249	WP_013119435.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
THERJR_RS02720	533608..533862	+	255	WP_013119436.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
THERJR_RS02725	533855..534187	+	333	WP_013119437.1	type II toxin-antitoxin system RelE/ParE family toxin	-
THERJR_RS16155	534188..534319	+	132	Protein_532	(2Fe-2S)-binding protein	-
THERJR_RS02730	534515..534781	-	267	WP_013119438.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
THERJR_RS16320	534899..535078	+	180	WP_198360513.1	hypothetical protein	-
THERJR_RS02735	535141..537279	+	2139	WP_041587654.1	ATP-dependent RecD-like DNA helicase	-
THERJR_RS02740	537447..537695	+	249	WP_013119440.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (4-103)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12337.36 Da
• Isoelectric Point: 9.1395

>T24760 WP_013119434.1 NC_014152:c532705-532373 [Thermincola potens JR]
MTTYTPAQGDIIWLNFTPQSGHEQMGKMPALVISNDFFNKQTGLTIVCPITSTKRNYPLHVKTEGCKKISGYIMVEQVKA
VDYTSRKARFIEKAPVEVLAEVLARHSACF

Nucleotide

• Length: 333 bp

>T24760 NC_014152:c532705-532373 [Thermincola potens JR]
ATGACAACTTATACTCCGGCCCAAGGGGACATTATATGGTTAAATTTCACTCCTCAGTCGGGACACGAACAGATGGGAAA
AATGCCCGCTTTGGTAATTAGCAATGACTTCTTCAACAAACAGACCGGCCTTACAATAGTATGCCCTATTACATCCACAA
AAAGAAATTACCCCCTTCACGTGAAAACTGAAGGATGCAAAAAAATTTCCGGCTACATCATGGTGGAGCAAGTAAAAGCT
GTCGACTATACCTCCCGGAAGGCCAGGTTTATTGAAAAAGCCCCCGTTGAAGTCCTCGCAGAGGTTCTGGCTAGGCATTC
TGCGTGTTTTTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9668.11 Da
• Isoelectric Point: 5.2410

>AT24760 WP_013119435.1 NC_014152:c532955-532707 [Thermincola potens JR]
MMAKIQKWGNSQGIRIPKQLLAIASIKEDDEVELIAEYGKIIIRRARKKEKKYTIQELFADYKAEYTPDEEEWGPPVGRE
EW

Nucleotide

• Length: 249 bp

>AT24760 NC_014152:c532955-532707 [Thermincola potens JR]
ATGATGGCAAAAATTCAAAAATGGGGTAACAGTCAGGGAATCAGAATTCCCAAACAGCTTCTTGCCATTGCTTCCATTAA
GGAAGACGACGAAGTTGAACTAATTGCAGAGTACGGCAAAATAATTATCCGCCGTGCCAGGAAAAAGGAAAAAAAATACA
CCATTCAAGAACTCTTTGCAGATTATAAAGCTGAATATACTCCTGACGAAGAAGAATGGGGTCCGCCGGTGGGCAGGGAG
GAGTGGTAA

Structures

Toxin

• AlphaFold DB: D5XB91

Antitoxin

• AlphaFold DB: D5XB92