Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 532373..532955 Replicon chromosome
Accession NC_014152
Organism Thermincola potens JR

Toxin (Protein)


Gene name mazF Uniprot ID D5XB91
Locus tag THERJR_RS02705 Protein ID WP_013119434.1
Coordinates 532373..532705 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID D5XB92
Locus tag THERJR_RS02710 Protein ID WP_013119435.1
Coordinates 532707..532955 (-) Length 83 a.a.

Genomic Context

THERJR_RS02680THERJR_RS02720THERJR_RS02725THERJR_RS16155THERJR_RS16320THERJR_RS02735THERJR_RS02740THERJR_RS02685THERJR_RS02690THERJR_RS02695THERJR_RS02700THERJR_RS02705THERJR_RS02710THERJR_RS02730
Location: 527947..528843 (897 bp)
Type: Others
Protein ID: WP_013119430.1
Location: 533608..533862 (255 bp)
Type: Others
Protein ID: WP_013119436.1
Location: 533855..534187 (333 bp)
Type: Others
Protein ID: WP_013119437.1
Location: 534188..534319 (132 bp)
Type: Others
Protein ID: Protein_532
Location: 534899..535078 (180 bp)
Type: Others
Protein ID: WP_198360513.1
Location: 535141..537279 (2139 bp)
Type: Others
Protein ID: WP_041587654.1
Location: 537447..537695 (249 bp)
Type: Others
Protein ID: WP_013119440.1
Location: 528874..529914 (1041 bp)
Type: Others
Protein ID: WP_013119431.1
Location: 530078..530824 (747 bp)
Type: Others
Protein ID: WP_013119432.1
Location: 531639..531875 (237 bp)
Type: Others
Protein ID: WP_157723909.1
Location: 531906..532256 (351 bp)
Type: Others
Protein ID: WP_157723910.1
Location: 532373..532705 (333 bp)
Type: Toxin
Protein ID: WP_013119434.1
Location: 532707..532955 (249 bp)
Type: Antitoxin
Protein ID: WP_013119435.1
Location: 534515..534781 (267 bp)
Type: Others
Protein ID: WP_013119438.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
THERJR_RS02680527947..528843+897WP_013119430.1LysR family transcriptional regulator-
THERJR_RS02685528874..529914-1041WP_013119431.1putative sulfate exporter family transporter-
THERJR_RS02690530078..530824-747WP_013119432.1adenosylcobinamide-GDP ribazoletransferase-
THERJR_RS02695531639..531875-237WP_157723909.1hypothetical protein-
THERJR_RS02700531906..532256-351WP_157723910.1hypothetical protein-
THERJR_RS02705532373..532705-333WP_013119434.1type II toxin-antitoxin system PemK/MazF family toxinToxin
THERJR_RS02710532707..532955-249WP_013119435.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
THERJR_RS02720533608..533862+255WP_013119436.1type II toxin-antitoxin system prevent-host-death family antitoxin-
THERJR_RS02725533855..534187+333WP_013119437.1type II toxin-antitoxin system RelE/ParE family toxin-
THERJR_RS16155534188..534319+132Protein_532(2Fe-2S)-binding protein-
THERJR_RS02730534515..534781-267WP_013119438.1type II toxin-antitoxin system Phd/YefM family antitoxin-
THERJR_RS16320534899..535078+180WP_198360513.1hypothetical protein-
THERJR_RS02735535141..537279+2139WP_041587654.1ATP-dependent RecD-like DNA helicase-
THERJR_RS02740537447..537695+249WP_013119440.1type II toxin-antitoxin system prevent-host-death family antitoxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-103)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12337.36 Da        Isoelectric Point: 9.1395

>T24760 WP_013119434.1 NC_014152:c532705-532373 [Thermincola potens JR]
MTTYTPAQGDIIWLNFTPQSGHEQMGKMPALVISNDFFNKQTGLTIVCPITSTKRNYPLHVKTEGCKKISGYIMVEQVKA
VDYTSRKARFIEKAPVEVLAEVLARHSACF

Download         Length: 333 bp

>T24760 NC_014152:c532705-532373 [Thermincola potens JR]
ATGACAACTTATACTCCGGCCCAAGGGGACATTATATGGTTAAATTTCACTCCTCAGTCGGGACACGAACAGATGGGAAA
AATGCCCGCTTTGGTAATTAGCAATGACTTCTTCAACAAACAGACCGGCCTTACAATAGTATGCCCTATTACATCCACAA
AAAGAAATTACCCCCTTCACGTGAAAACTGAAGGATGCAAAAAAATTTCCGGCTACATCATGGTGGAGCAAGTAAAAGCT
GTCGACTATACCTCCCGGAAGGCCAGGTTTATTGAAAAAGCCCCCGTTGAAGTCCTCGCAGAGGTTCTGGCTAGGCATTC
TGCGTGTTTTTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9668.11 Da        Isoelectric Point: 5.2410

>AT24760 WP_013119435.1 NC_014152:c532955-532707 [Thermincola potens JR]
MMAKIQKWGNSQGIRIPKQLLAIASIKEDDEVELIAEYGKIIIRRARKKEKKYTIQELFADYKAEYTPDEEEWGPPVGRE
EW

Download         Length: 249 bp

>AT24760 NC_014152:c532955-532707 [Thermincola potens JR]
ATGATGGCAAAAATTCAAAAATGGGGTAACAGTCAGGGAATCAGAATTCCCAAACAGCTTCTTGCCATTGCTTCCATTAA
GGAAGACGACGAAGTTGAACTAATTGCAGAGTACGGCAAAATAATTATCCGCCGTGCCAGGAAAAAGGAAAAAAAATACA
CCATTCAAGAACTCTTTGCAGATTATAAAGCTGAATATACTCCTGACGAAGAAGAATGGGGTCCGCCGGTGGGCAGGGAG
GAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBD5XB91

Antitoxin

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Source
ID
Structure
AlphaFold DBD5XB92

References