Detailed information of TA system TA024759

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3267809..3268476
• Replicon: chromosome
• Accession: NC_014151
• Organism: Cellulomonas flavigena DSM 20109

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: D5UKG6
• Locus tag: CFLA_RS14885
• Protein ID: WP_013118158.1
• Coordinates: 3268045..3268476 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: CFLA_RS14880
• Protein ID: WP_043599124.1
• Coordinates: 3267809..3268048 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CFLA_RS14860	3263625..3264527	+	903	WP_013118153.1	hypothetical protein	-
CFLA_RS14865	3264726..3265331	+	606	WP_013118154.1	pentapeptide repeat-containing protein	-
CFLA_RS14870	3265337..3265915	-	579	WP_013118155.1	GNAT family N-acetyltransferase	-
CFLA_RS14875	3266078..3267520	-	1443	WP_013118156.1	aminotransferase class V-fold PLP-dependent enzyme	-
CFLA_RS14880	3267809..3268048	+	240	WP_043599124.1	ribbon-helix-helix domain-containing protein	Antitoxin
CFLA_RS14885	3268045..3268476	+	432	WP_013118158.1	type II toxin-antitoxin system VapC family toxin	Toxin
CFLA_RS14890	3268489..3269028	-	540	WP_013118159.1	GNAT family N-acetyltransferase	-
CFLA_RS14895	3269231..3269674	+	444	WP_013118160.1	sulfurtransferase	-
CFLA_RS14900	3269683..3270930	+	1248	WP_052302867.1	O-succinylhomoserine sulfhydrylase	-
CFLA_RS14905	3271024..3271554	-	531	WP_013118162.1	hypothetical protein	-
CFLA_RS14910	3271685..3272695	+	1011	WP_013118163.1	aldo/keto reductase family protein	-
CFLA_RS14915	3272771..3273286	-	516	WP_013118164.1	pyridoxamine 5'-phosphate oxidase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-138)

Antitoxin

• Ribbon-helix-helix protein, CopG (2-40)

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15477.58 Da
• Isoelectric Point: 6.4881

>T24759 WP_013118158.1 NC_014151:3268045-3268476 [Cellulomonas flavigena DSM 20109]
VILPDVNVLVGALRADSPRHDALRRWLEAAVDAPEPLGLTDAVLGGTVRVLTHPRVFARPTPLRTALDLVGDLRAHPGTV
RVAPGDRHWEIVADLCRAADARGNLVADAQHAAVAVEHGATWVSQDRDFARFPGLRWQVAVED

Nucleotide

• Length: 432 bp

>T24759 NC_014151:3268045-3268476 [Cellulomonas flavigena DSM 20109]
GTGATCCTGCCGGACGTCAACGTGCTGGTGGGCGCCCTGCGTGCCGACTCGCCCCGGCACGACGCGCTGCGCCGGTGGCT
CGAGGCCGCCGTCGACGCCCCCGAGCCGCTCGGGCTGACCGACGCGGTGCTCGGCGGCACCGTCCGCGTCCTCACGCACC
CCCGCGTGTTCGCCCGTCCGACGCCGCTGCGTACGGCGCTCGACCTCGTGGGGGACCTGCGGGCGCACCCCGGCACGGTC
CGCGTCGCCCCCGGCGACAGGCACTGGGAGATCGTCGCCGACCTGTGCCGGGCCGCGGACGCCCGCGGCAACCTCGTCGC
GGACGCGCAGCACGCCGCCGTGGCGGTCGAGCACGGGGCGACCTGGGTGTCGCAGGACCGTGACTTCGCGCGGTTCCCCG
GCCTGCGGTGGCAGGTGGCCGTCGAGGACTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.68 Da
• Isoelectric Point: 4.7962

>AT24759 WP_043599124.1 NC_014151:3267809-3268048 [Cellulomonas flavigena DSM 20109]
MRTTLHLPDELYREVKAAAARSGRTVTSVVEDALRAELERFRATAERPPFRIDAVGSGGLLPGVDLDDSAALLDVLEGR

Nucleotide

• Length: 240 bp

>AT24759 NC_014151:3267809-3268048 [Cellulomonas flavigena DSM 20109]
ATGCGCACCACCCTGCACCTCCCCGACGAGCTCTACCGCGAGGTCAAGGCGGCGGCCGCGCGATCCGGACGCACCGTGAC
GTCCGTGGTCGAGGACGCGTTGCGCGCCGAGCTCGAGCGGTTCCGCGCGACGGCCGAGCGGCCACCCTTCCGCATCGACG
CGGTCGGCAGCGGCGGGCTGCTGCCCGGGGTCGACCTCGACGACTCCGCGGCACTGCTCGACGTCCTGGAGGGCCGGTGA

Structures

Toxin

• AlphaFold DB: D5UKG6