Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higB-toxA/Tad-HTH_37
Location 482230..482858 Replicon chromosome
Accession NZ_CP098411
Organism Lacticaseibacillus paracasei strain 401

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NCY29_RS02190 Protein ID WP_003583266.1
Coordinates 482490..482858 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag NCY29_RS02185 Protein ID WP_003583264.1
Coordinates 482230..482490 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NCY29_RS02155 (NCY29_02155) 478019..478549 + 531 WP_012490988.1 DNA-directed RNA polymerase subunit sigma-24 -
NCY29_RS02160 (NCY29_02160) 478717..478869 + 153 WP_003563363.1 YvrJ family protein -
NCY29_RS02165 (NCY29_02165) 478879..479643 + 765 WP_250786050.1 GH25 family lysozyme -
NCY29_RS02170 (NCY29_02170) 479854..480357 + 504 WP_063557854.1 TetR/AcrR family transcriptional regulator -
NCY29_RS02175 (NCY29_02175) 480362..481423 + 1062 WP_016373561.1 ABC transporter permease -
NCY29_RS02180 (NCY29_02180) 481428..482117 + 690 WP_003583263.1 ABC transporter ATP-binding protein -
NCY29_RS02185 (NCY29_02185) 482230..482490 - 261 WP_003583264.1 helix-turn-helix transcriptional regulator Antitoxin
NCY29_RS02190 (NCY29_02190) 482490..482858 - 369 WP_003583266.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NCY29_RS02195 (NCY29_02195) 483149..484519 - 1371 WP_003573580.1 FAD-dependent oxidoreductase -
NCY29_RS02200 (NCY29_02200) 484883..485701 - 819 WP_011674103.1 Cof-type HAD-IIB family hydrolase -
NCY29_RS02205 (NCY29_02205) 486012..486281 - 270 WP_003563382.1 type II toxin-antitoxin system YafQ family toxin -
NCY29_RS02210 (NCY29_02210) 486522..487529 + 1008 WP_003563383.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(34-112)

Antitoxin

Cro/C1-type helix-turn-helix domain

(28-79)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 14939.01 Da        Isoelectric Point: 8.3986

>T247586 WP_003583266.1 NZ_CP098411:c482858-482490 [Lacticaseibacillus paracasei]
MYKIDFYEDRDGYSEIEDFLDQLRHSHQKNNVSLLNKITKELYMLQNLGPRLREPHAKFLKGYAYPIMELRPMPERIFYA
AWQKDHFVLLHHYTKKTNKTDHREILRAQSNLEDWLSRKEEN

Download         Length: 369 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9828.45 Da        Isoelectric Point: 10.2439

>AT247586 WP_003583264.1 NZ_CP098411:c482490-482230 [Lacticaseibacillus paracasei]
MTTWEDFSQKLKKDNPEKLAIIKTLADLESERIKQGISQKDFAEKIGMKQPQLAKIERLDSLPTLATLNRYARGLGKEIR
LSIVTQ

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References