Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1430314..1430902 Replicon chromosome
Accession NZ_CP098400
Organism Alkaliflexus sp. Ai-910

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag M9189_RS06000 Protein ID WP_250725391.1
Coordinates 1430314..1430613 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag M9189_RS06005 Protein ID WP_250725393.1
Coordinates 1430618..1430902 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9189_RS05980 (M9189_05980) 1427028..1428191 - 1164 WP_250723552.1 IS4 family transposase -
M9189_RS05985 (M9189_05985) 1428454..1428807 + 354 WP_088656172.1 hypothetical protein -
M9189_RS05990 (M9189_05990) 1428800..1429855 + 1056 WP_250723317.1 transposase -
M9189_RS05995 (M9189_05995) 1429900..1430049 + 150 WP_250725390.1 hypothetical protein -
M9189_RS06000 (M9189_06000) 1430314..1430613 + 300 WP_250725391.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M9189_RS06005 (M9189_06005) 1430618..1430902 + 285 WP_250725393.1 putative addiction module antidote protein Antitoxin
M9189_RS06010 (M9189_06010) 1431205..1432005 - 801 WP_250725395.1 transposase -
M9189_RS06015 (M9189_06015) 1432099..1433013 - 915 WP_250725397.1 tyrosine-type recombinase/integrase -
M9189_RS06020 (M9189_06020) 1433255..1433764 + 510 WP_250725398.1 hypothetical protein -
M9189_RS06025 (M9189_06025) 1434216..1434590 + 375 WP_250725400.1 hypothetical protein -
M9189_RS06030 (M9189_06030) 1434593..1434958 + 366 WP_062129131.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1430314..1453852 23538


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-95)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11757.88 Da        Isoelectric Point: 10.2794

>T247581 WP_250725391.1 NZ_CP098400:1430314-1430613 [Alkaliflexus sp. Ai-910]
MYIIEKTEEFDKWLRKLKDLRAKAKILFRIQKIENDEHFGDCKLVGNGIRELKIDFAKGYRVYFKESDGKIIILLIGGDK
STQQRDIEKAKEILKRIKK

Download         Length: 300 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10090.63 Da        Isoelectric Point: 4.7023

>AT247581 WP_250725393.1 NZ_CP098400:1430618-1430902 [Alkaliflexus sp. Ai-910]
MGTSKFDIADYLDSNEMIAEYLNTVLAEGNEADVIVAIGHIAKSIGMTKIAQETGLSRTSLYKALSEGAKPQFETIMKVL
KAIGGQIQINPMNA

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References