Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1022869..1023500 Replicon chromosome
Accession NC_014151
Organism Cellulomonas flavigena DSM 20109

Toxin (Protein)


Gene name vapC Uniprot ID D5UKM5
Locus tag CFLA_RS04695 Protein ID WP_013116177.1
Coordinates 1023087..1023500 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D5UKM4
Locus tag CFLA_RS04690 Protein ID WP_013116176.1
Coordinates 1022869..1023096 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFLA_RS04670 1018166..1019437 - 1272 WP_013116172.1 FAD-binding protein -
CFLA_RS04675 1019464..1020246 - 783 WP_148234478.1 CPBP family intramembrane metalloprotease -
CFLA_RS04680 1020489..1020929 - 441 WP_148234284.1 hypothetical protein -
CFLA_RS04685 1021204..1022772 - 1569 WP_013116175.1 ATP-dependent DNA ligase -
CFLA_RS04690 1022869..1023096 + 228 WP_013116176.1 hypothetical protein Antitoxin
CFLA_RS04695 1023087..1023500 + 414 WP_013116177.1 ribonuclease Toxin
CFLA_RS04700 1023824..1024453 - 630 WP_148234479.1 peptide-methionine (S)-S-oxide reductase MsrA -
CFLA_RS04705 1024619..1025854 + 1236 WP_013116179.1 cystathionine gamma-synthase -
CFLA_RS04710 1025878..1027113 + 1236 WP_148234480.1 AI-2E family transporter -
CFLA_RS04715 1027110..1028309 + 1200 WP_013116181.1 threonine ammonia-lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14842.21 Da        Isoelectric Point: 6.4880

>T24758 WP_013116177.1 NC_014151:1023087-1023500 [Cellulomonas flavigena DSM 20109]
MAVTTWLVDKSALVRLPYAVERDLWQARLERGLLRLAHVTRLEVGFSALSGRSAREAASAPPVSLMPVEHLTPGIEARAL
EVQTLLADRGEHRAASIPDLLVAATAEKLGMTVLAVDKGFDLIAHVTGQPVERLAFE

Download         Length: 414 bp

>T24758 NC_014151:1023087-1023500 [Cellulomonas flavigena DSM 20109]
ATGGCGGTGACGACCTGGCTCGTGGACAAGTCCGCGCTCGTCCGCCTGCCCTACGCGGTGGAACGTGACCTGTGGCAGGC
GCGGCTGGAGCGTGGTCTGCTCCGCCTGGCCCACGTCACGCGGCTCGAGGTCGGGTTCTCGGCCCTCTCGGGTCGCAGTG
CCCGCGAGGCCGCGTCCGCGCCACCCGTCTCGCTCATGCCGGTGGAGCACCTGACGCCCGGGATCGAGGCGCGGGCTCTG
GAGGTCCAGACCCTGCTCGCCGACCGTGGTGAGCACCGTGCGGCGTCGATCCCCGACCTGCTCGTGGCGGCGACCGCCGA
GAAGCTCGGCATGACGGTGCTCGCCGTCGACAAGGGCTTCGACCTCATCGCACATGTCACCGGGCAGCCCGTCGAGCGCC
TCGCGTTCGAGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8319.31 Da        Isoelectric Point: 4.4536

>AT24758 WP_013116176.1 NC_014151:1022869-1023096 [Cellulomonas flavigena DSM 20109]
MPDILVRGLSEAAVAHFDAEAASLGLSRAEVLRRHLEAEVRADAPRPTMTPDDWDRFAREFGDLGDPEVMASAWR

Download         Length: 228 bp

>AT24758 NC_014151:1022869-1023096 [Cellulomonas flavigena DSM 20109]
ATGCCCGACATCCTCGTCCGCGGTCTCTCCGAGGCCGCGGTCGCCCACTTCGACGCCGAGGCCGCCAGCCTCGGGCTCTC
TCGTGCCGAGGTGCTGCGCCGGCACCTCGAGGCCGAGGTCCGTGCGGACGCGCCGCGTCCCACGATGACCCCCGACGACT
GGGACCGGTTCGCGCGGGAGTTCGGCGACCTCGGTGACCCCGAGGTGATGGCGTCCGCATGGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D5UKM5

Antitoxin

Source ID Structure
AlphaFold DB D5UKM4

References