Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 47266..47813 Replicon plasmid p52977-166.3
Accession NZ_CP098354
Organism Klebsiella pneumoniae strain 52977_A1

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag NB671_RS28190 Protein ID WP_244461643.1
Coordinates 47266..47544 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag NB671_RS28195 Protein ID WP_000079941.1
Coordinates 47544..47813 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB671_RS28160 (42376) 42376..43410 - 1035 WP_001190234.1 3-deoxy-7-phosphoheptulonate synthase -
NB671_RS28165 (43707) 43707..44738 + 1032 WP_001752311.1 IS630-like element ISEc33 family transposase -
NB671_RS28170 (44758) 44758..45046 + 289 Protein_34 hypothetical protein -
NB671_RS28175 (45124) 45124..45471 - 348 WP_000142437.1 DUF6404 family protein -
NB671_RS28180 (45773) 45773..46255 - 483 WP_001311056.1 hypothetical protein -
NB671_RS28185 (46372) 46372..47220 - 849 WP_001058005.1 3'-5' exonuclease -
NB671_RS28190 (47266) 47266..47544 - 279 WP_244461643.1 type II toxin-antitoxin system toxin YacB Toxin
NB671_RS28195 (47544) 47544..47813 - 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
NB671_RS28200 (48335) 48335..49563 + 1229 WP_172692618.1 IS3-like element IS2 family transposase -
NB671_RS28205 (49760) 49760..51034 + 1275 WP_000489607.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(A) / sitABCD iroB / iroC / iroD / iroE / iroN / iutA / iucD / iucC / iucB / iucA 1..166337 166337
- inside IScluster/Tn - - 41154..49563 8409


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10757.34 Da        Isoelectric Point: 8.4615

>T247555 WP_244461643.1 NZ_CP098354:c47544-47266 [Klebsiella pneumoniae]
MEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGYSASNLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRGLHTVQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT247555 WP_000079941.1 NZ_CP098354:c47813-47544 [Klebsiella pneumoniae]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References