Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4881886..4882402 Replicon chromosome
Accession NZ_CP098352
Organism Klebsiella pneumoniae strain 52977_A1

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag NB671_RS24000 Protein ID WP_002886902.1
Coordinates 4881886..4882170 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NB671_RS24005 Protein ID WP_002886901.1
Coordinates 4882160..4882402 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB671_RS23975 (NB671_23975) 4877370..4877633 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
NB671_RS23980 (NB671_23980) 4877763..4877936 + 174 WP_002886906.1 hypothetical protein -
NB671_RS23985 (NB671_23985) 4877939..4878682 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NB671_RS23990 (NB671_23990) 4879039..4881177 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
NB671_RS23995 (NB671_23995) 4881418..4881882 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NB671_RS24000 (NB671_24000) 4881886..4882170 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NB671_RS24005 (NB671_24005) 4882160..4882402 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NB671_RS24010 (NB671_24010) 4882480..4884390 - 1911 WP_004152270.1 PRD domain-containing protein -
NB671_RS24015 (NB671_24015) 4884413..4885567 - 1155 WP_002886900.1 lactonase family protein -
NB671_RS24020 (NB671_24020) 4885633..4886373 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T247550 WP_002886902.1 NZ_CP098352:c4882170-4881886 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT247550 WP_002886901.1 NZ_CP098352:c4882402-4882160 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References