Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2781991..2783579 Replicon chromosome
Accession NZ_CP098350
Organism Klebsiella pneumoniae strain 52980_A4

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag NB670_RS13610 Protein ID WP_002904792.1
Coordinates 2781991..2783313 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NB670_RS13615 Protein ID WP_002904790.1
Coordinates 2783313..2783579 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB670_RS13595 (NB670_13595) 2777047..2779548 + 2502 WP_004151634.1 fimbria/pilus outer membrane usher protein -
NB670_RS13600 (NB670_13600) 2779536..2780540 + 1005 WP_073668860.1 fimbrial protein -
NB670_RS13605 (NB670_13605) 2780682..2781974 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NB670_RS13610 (NB670_13610) 2781991..2783313 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
NB670_RS13615 (NB670_13615) 2783313..2783579 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NB670_RS13620 (NB670_13620) 2783845..2784171 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NB670_RS13625 (NB670_13625) 2784168..2784668 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NB670_RS13630 (NB670_13630) 2784646..2786025 - 1380 WP_002904785.1 nucleobase:cation symporter-2 family protein -
NB670_RS13635 (NB670_13635) 2786371..2787525 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NB670_RS13640 (NB670_13640) 2787506..2788429 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T247531 WP_002904792.1 NZ_CP098350:c2783313-2781991 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT247531 WP_002904790.1 NZ_CP098350:c2783579-2783313 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References