Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4332837..4333497 Replicon chromosome
Accession NC_014121
Organism Enterobacter cloacae subsp. cloacae ATCC 13047

Toxin (Protein)


Gene name cptA Uniprot ID A0A5E1AGQ2
Locus tag ECL_RS21050 Protein ID WP_023620447.1
Coordinates 4332837..4333250 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A5E1AG01
Locus tag ECL_RS21055 Protein ID WP_013098615.1
Coordinates 4333231..4333497 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECL_RS21030 4328830..4330563 - 1734 WP_013098610.1 single-stranded-DNA-specific exonuclease RecJ -
ECL_RS21035 4330569..4331282 - 714 WP_013098611.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ECL_RS21040 4331311..4332207 - 897 WP_013098612.1 site-specific tyrosine recombinase XerD -
ECL_RS21045 4332309..4332830 + 522 WP_013098613.1 flavodoxin FldB -
ECL_RS21050 4332837..4333250 - 414 WP_023620447.1 protein YgfX Toxin
ECL_RS21055 4333231..4333497 - 267 WP_013098615.1 FAD assembly factor SdhE Antitoxin
ECL_RS21060 4333792..4334772 + 981 WP_013098616.1 tRNA-modifying protein YgfZ -
ECL_RS21065 4334882..4335541 - 660 WP_003863433.1 hemolysin III family protein -
ECL_RS21070 4335807..4336538 + 732 WP_013098618.1 MurR/RpiR family transcriptional regulator -
ECL_RS21075 4336655..4338088 + 1434 WP_013098619.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16220.21 Da        Isoelectric Point: 10.9554

>T24752 WP_023620447.1 NC_014121:c4333250-4332837 [Enterobacter cloacae subsp. cloacae ATCC 13047]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLSSGMMLRLRQVGGGKCQHLWLAADSMDIAEWRELRRMLLQQQPTQE

Download         Length: 414 bp

>T24752 NC_014121:c4333250-4332837 [Enterobacter cloacae subsp. cloacae ATCC 13047]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTATTGCTCCACGGCCTGGTCGCGGC
ATTTGTTTTACTGATGCCGTGGCCGCTTAGCTATACGCCGCTGTGGCTGTTGTTGCTGTCGTTCGTCGTTTTTGACAGCG
TGCGCAGCCAGCGCCGGATCAATGCCCGCCAGGGTGAGATTAAATTACTGATGGACTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATCCTCGGTATGCCCTGGATGCTCAGTTCCGGCATGATGCTACGGTTACGCCAGGTGGGCGGCGGTAAGTG
CCAGCATCTGTGGCTGGCCGCCGACAGTATGGATATTGCGGAGTGGCGGGAACTGCGCCGGATGCTACTGCAGCAGCAAC
CGACGCAGGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1456

>AT24752 WP_013098615.1 NC_014121:c4333497-4333231 [Enterobacter cloacae subsp. cloacae ATCC 13047]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDEDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT24752 NC_014121:c4333497-4333231 [Enterobacter cloacae subsp. cloacae ATCC 13047]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCATGCCGACGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGAGGATAAGCGTCTGTTTGTTCGCCTGCTTGAATCTGACGATCCCGATT
TATTCAACTGGCTGATGAACCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E1AGQ2

Antitoxin

Source ID Structure
AlphaFold DB A0A5E1AG01

References