Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2782264..2783852 Replicon chromosome
Accession NZ_CP098347
Organism Klebsiella pneumoniae strain 52984_A8

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag NB669_RS13625 Protein ID WP_002904792.1
Coordinates 2782264..2783586 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NB669_RS13630 Protein ID WP_002904790.1
Coordinates 2783586..2783852 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB669_RS13610 (NB669_13610) 2777320..2779821 + 2502 WP_004151634.1 fimbria/pilus outer membrane usher protein -
NB669_RS13615 (NB669_13615) 2779809..2780813 + 1005 WP_073668860.1 fimbrial protein -
NB669_RS13620 (NB669_13620) 2780955..2782247 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NB669_RS13625 (NB669_13625) 2782264..2783586 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
NB669_RS13630 (NB669_13630) 2783586..2783852 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NB669_RS13635 (NB669_13635) 2784118..2784444 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NB669_RS13640 (NB669_13640) 2784441..2784941 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NB669_RS13645 (NB669_13645) 2784919..2786298 - 1380 WP_002904785.1 nucleobase:cation symporter-2 family protein -
NB669_RS13650 (NB669_13650) 2786644..2787798 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NB669_RS13655 (NB669_13655) 2787779..2788702 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T247505 WP_002904792.1 NZ_CP098347:c2783586-2782264 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT247505 WP_002904790.1 NZ_CP098347:c2783852-2783586 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References