Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 814692..815349 Replicon chromosome
Accession NZ_CP098347
Organism Klebsiella pneumoniae strain 52984_A8

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NB669_RS04075 Protein ID WP_002916310.1
Coordinates 814939..815349 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NB669_RS04070 Protein ID WP_002916312.1
Coordinates 814692..814958 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB669_RS04045 (NB669_04045) 809848..811281 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
NB669_RS04050 (NB669_04050) 811400..812128 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NB669_RS04055 (NB669_04055) 812178..812489 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
NB669_RS04060 (NB669_04060) 812653..813312 + 660 WP_002916317.1 hemolysin III family protein -
NB669_RS04065 (NB669_04065) 813463..814446 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
NB669_RS04070 (NB669_04070) 814692..814958 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NB669_RS04075 (NB669_04075) 814939..815349 + 411 WP_002916310.1 protein YgfX Toxin
NB669_RS04080 (NB669_04080) 815356..815877 - 522 WP_002916308.1 flavodoxin FldB -
NB669_RS04085 (NB669_04085) 815978..816874 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NB669_RS04090 (NB669_04090) 816897..817610 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NB669_RS04095 (NB669_04095) 817616..819349 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T247500 WP_002916310.1 NZ_CP098347:814939-815349 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT247500 WP_002916312.1 NZ_CP098347:814692-814958 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References