Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5464194..5464819 Replicon chromosome
Accession NZ_CP098340
Organism Klebsiella pneumoniae strain 53015_G7

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag NB667_RS26875 Protein ID WP_002882817.1
Coordinates 5464194..5464577 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag NB667_RS26880 Protein ID WP_004150355.1
Coordinates 5464577..5464819 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB667_RS26860 (NB667_26865) 5461560..5462462 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
NB667_RS26865 (NB667_26870) 5462459..5463094 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
NB667_RS26870 (NB667_26875) 5463091..5464020 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
NB667_RS26875 (NB667_26880) 5464194..5464577 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
NB667_RS26880 (NB667_26885) 5464577..5464819 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
NB667_RS26885 (NB667_26890) 5465024..5465941 + 918 WP_002882812.1 alpha/beta hydrolase -
NB667_RS26890 (NB667_26895) 5465955..5466896 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
NB667_RS26895 (NB667_26900) 5466941..5467378 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
NB667_RS26900 (NB667_26905) 5467375..5468235 - 861 WP_002882807.1 virulence factor BrkB family protein -
NB667_RS26905 (NB667_26910) 5468229..5468828 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T247479 WP_002882817.1 NZ_CP098340:c5464577-5464194 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT247479 WP_004150355.1 NZ_CP098340:c5464819-5464577 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References