Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5079303..5080984 Replicon chromosome
Accession NZ_CP098338
Organism Klebsiella pneumoniae strain 53022_J1

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag NB666_RS25055 Protein ID WP_002885155.1
Coordinates 5079303..5080220 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag NB666_RS25060 Protein ID WP_004151732.1
Coordinates 5080226..5080984 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB666_RS25035 (NB666_25035) 5074609..5076129 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
NB666_RS25040 (NB666_25040) 5076126..5077124 + 999 WP_002885172.1 ribose ABC transporter permease -
NB666_RS25045 (NB666_25045) 5077155..5078096 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
NB666_RS25050 (NB666_25050) 5078171..5079178 + 1008 WP_004151731.1 carbohydrate kinase family protein -
NB666_RS25055 (NB666_25055) 5079303..5080220 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NB666_RS25060 (NB666_25060) 5080226..5080984 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
NB666_RS25065 (NB666_25065) 5081070..5081798 - 729 WP_002885152.1 response regulator transcription factor -
NB666_RS25070 (NB666_25070) 5082071..5084218 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
NB666_RS25075 (NB666_25075) 5084448..5085134 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T247462 WP_002885155.1 NZ_CP098338:c5080220-5079303 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT247462 WP_004151732.1 NZ_CP098338:c5080984-5080226 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References