Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 873425..874082 Replicon chromosome
Accession NZ_CP098338
Organism Klebsiella pneumoniae strain 53022_J1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NB666_RS04410 Protein ID WP_002916310.1
Coordinates 873672..874082 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NB666_RS04405 Protein ID WP_002916312.1
Coordinates 873425..873691 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB666_RS04380 (NB666_04380) 868581..870014 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
NB666_RS04385 (NB666_04385) 870133..870861 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NB666_RS04390 (NB666_04390) 870911..871222 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
NB666_RS04395 (NB666_04395) 871386..872045 + 660 WP_002916317.1 hemolysin III family protein -
NB666_RS04400 (NB666_04400) 872196..873179 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
NB666_RS04405 (NB666_04405) 873425..873691 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NB666_RS04410 (NB666_04410) 873672..874082 + 411 WP_002916310.1 protein YgfX Toxin
NB666_RS04415 (NB666_04415) 874089..874610 - 522 WP_002916308.1 flavodoxin FldB -
NB666_RS04420 (NB666_04420) 874711..875607 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NB666_RS04425 (NB666_04425) 875630..876343 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NB666_RS04430 (NB666_04430) 876349..878082 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T247453 WP_002916310.1 NZ_CP098338:873672-874082 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT247453 WP_002916312.1 NZ_CP098338:873425-873691 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References