Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5067676..5069357 Replicon chromosome
Accession NZ_CP098335
Organism Klebsiella pneumoniae strain 53023_J2

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag NB665_RS25015 Protein ID WP_002885155.1
Coordinates 5067676..5068593 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag NB665_RS25020 Protein ID WP_004151732.1
Coordinates 5068599..5069357 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB665_RS24995 (NB665_24995) 5062982..5064502 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
NB665_RS25000 (NB665_25000) 5064499..5065497 + 999 WP_002885172.1 ribose ABC transporter permease -
NB665_RS25005 (NB665_25005) 5065528..5066469 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
NB665_RS25010 (NB665_25010) 5066544..5067551 + 1008 WP_004151731.1 carbohydrate kinase family protein -
NB665_RS25015 (NB665_25015) 5067676..5068593 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NB665_RS25020 (NB665_25020) 5068599..5069357 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
NB665_RS25025 (NB665_25025) 5069443..5070171 - 729 WP_002885152.1 response regulator transcription factor -
NB665_RS25030 (NB665_25030) 5070444..5072591 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
NB665_RS25035 (NB665_25035) 5072821..5073507 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T247446 WP_002885155.1 NZ_CP098335:c5068593-5067676 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT247446 WP_004151732.1 NZ_CP098335:c5069357-5068599 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References