Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2810546..2812134 Replicon chromosome
Accession NZ_CP098335
Organism Klebsiella pneumoniae strain 53023_J2

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag NB665_RS13830 Protein ID WP_002904792.1
Coordinates 2810546..2811868 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NB665_RS13835 Protein ID WP_002904790.1
Coordinates 2811868..2812134 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB665_RS13815 (NB665_13815) 2805602..2808103 + 2502 WP_004151634.1 fimbria/pilus outer membrane usher protein -
NB665_RS13820 (NB665_13820) 2808091..2809095 + 1005 WP_073668860.1 fimbrial protein -
NB665_RS13825 (NB665_13825) 2809237..2810529 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NB665_RS13830 (NB665_13830) 2810546..2811868 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
NB665_RS13835 (NB665_13835) 2811868..2812134 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NB665_RS13840 (NB665_13840) 2812400..2812726 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NB665_RS13845 (NB665_13845) 2812723..2813223 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NB665_RS13850 (NB665_13850) 2813201..2814580 - 1380 WP_002904785.1 nucleobase:cation symporter-2 family protein -
NB665_RS13855 (NB665_13855) 2814926..2816080 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NB665_RS13860 (NB665_13860) 2816061..2816984 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T247442 WP_002904792.1 NZ_CP098335:c2811868-2810546 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT247442 WP_002904790.1 NZ_CP098335:c2812134-2811868 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References