247430

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 4855124..4855790 Replicon chromosome
Accession NZ_CP098330
Organism Citrobacter freundii strain 59174

Toxin (Protein)


Gene name tad Uniprot ID A0A0D7LIM5
Locus tag NB664_RS23880 Protein ID WP_044702260.1
Coordinates 4855431..4855790 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A0D7LIR0
Locus tag NB664_RS23875 Protein ID WP_003844682.1
Coordinates 4855124..4855441 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB664_RS23845 (4850791) 4850791..4851615 + 825 WP_003031641.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
NB664_RS23850 (4851684) 4851684..4852907 + 1224 WP_044702265.1 L-sorbose 1-phosphate reductase -
NB664_RS23855 (4852909) 4852909..4853721 + 813 WP_044702264.1 shikimate 5-dehydrogenase -
NB664_RS23860 (4853773) 4853773..4854129 - 357 WP_032948294.1 hypothetical protein -
NB664_RS23865 (4854271) 4854271..4854432 + 162 WP_003841416.1 phage protein -
NB664_RS23870 (4854836) 4854836..4855114 + 279 WP_044702262.1 putative addiction module antidote protein -
NB664_RS23875 (4855124) 4855124..4855441 - 318 WP_003844682.1 helix-turn-helix transcriptional regulator Antitoxin
NB664_RS23880 (4855431) 4855431..4855790 - 360 WP_044702260.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NB664_RS23885 (4856004) 4856004..4856693 + 690 WP_003841421.1 dipeptidase PepE -
NB664_RS23890 (4856759) 4856759..4858390 - 1632 WP_032938230.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-90)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13437.49 Da        Isoelectric Point: 10.2555

>T247430 WP_044702260.1 NZ_CP098330:c4855790-4855431 [Citrobacter freundii]
MTKPLYWVGQARKDLIAMPEHVRDTFGFALWLAQQGKQHSQTKPLKGFGGAGVLEVVEDYHGNAWRAVYTIQLKNAVYVL
HVFQKKSVSGKATPKPEIDLIYQRLKAAQRHAQESGYVT

Download         Length: 360 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11466.35 Da        Isoelectric Point: 9.0005

>AT247430 WP_003844682.1 NZ_CP098330:c4855441-4855124 [Citrobacter freundii]
MSHDVETSSGNVYADLGAYDAEQMQLKAQLAMVIGEILQRKGLTQQQAAQLLGMTQPKLSNLLRGQFRGISEAKMLECLV
RLGRDVEIVVGKEGNMSGKLKVKFG

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D7LIM5

Antitoxin

Source ID Structure
AlphaFold DB A0A0D7LIR0

References