Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4598992..4599508 Replicon chromosome
Accession NZ_CP098330
Organism Citrobacter freundii strain 59174

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NB664_RS22660 Protein ID WP_044699148.1
Coordinates 4598992..4599276 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0J1MV10
Locus tag NB664_RS22665 Protein ID WP_003839576.1
Coordinates 4599266..4599508 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB664_RS22645 (4595317) 4595317..4595901 + 585 WP_003839584.1 fructose PTS transporter subunit IIA -
NB664_RS22650 (4596279) 4596279..4598417 + 2139 WP_003025782.1 anaerobic ribonucleoside-triphosphate reductase -
NB664_RS22655 (4598524) 4598524..4598988 + 465 WP_032937736.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NB664_RS22660 (4598992) 4598992..4599276 - 285 WP_044699148.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NB664_RS22665 (4599266) 4599266..4599508 - 243 WP_003839576.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NB664_RS22670 (4599586) 4599586..4601499 - 1914 WP_003839574.1 BglG family transcription antiterminator -
NB664_RS22675 (4601521) 4601521..4602261 - 741 WP_044699149.1 KDGP aldolase family protein -
NB664_RS22680 (4602258) 4602258..4603376 - 1119 WP_044699152.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NB664_RS22685 (4603360) 4603360..4604493 - 1134 WP_016149471.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10865.69 Da        Isoelectric Point: 10.1988

>T247429 WP_044699148.1 NZ_CP098330:c4599276-4598992 [Citrobacter freundii]
MTYELEFDPRALKEWHKLGDTVKAQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVTVFVVAVGK
RQHSAVYLDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT247429 WP_003839576.1 NZ_CP098330:c4599508-4599266 [Citrobacter freundii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDTLIQTVRERLASPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MV10

References