247427

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3807122..3807742 Replicon chromosome
Accession NZ_CP098330
Organism Citrobacter freundii strain 59174

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag NB664_RS18695 Protein ID WP_002892050.1
Coordinates 3807524..3807742 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag NB664_RS18690 Protein ID WP_003021733.1
Coordinates 3807122..3807496 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB664_RS18680 (3802269) 3802269..3803462 + 1194 WP_003835922.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NB664_RS18685 (3803485) 3803485..3806634 + 3150 WP_003021736.1 efflux RND transporter permease AcrB -
NB664_RS18690 (3807122) 3807122..3807496 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
NB664_RS18695 (3807524) 3807524..3807742 + 219 WP_002892050.1 HHA domain-containing protein Toxin
NB664_RS18700 (3807876) 3807876..3808907 - 1032 WP_001395480.1 IS630-like element ISEc33 family transposase -
NB664_RS18705 (3809204) 3809204..3809755 + 552 WP_044699372.1 maltose O-acetyltransferase -
NB664_RS18710 (3809872) 3809872..3810342 + 471 WP_003021724.1 YlaC family protein -
NB664_RS18715 (3810421) 3810421..3810561 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
NB664_RS18720 (3810563) 3810563..3810823 - 261 WP_003021719.1 type B 50S ribosomal protein L31 -
NB664_RS18725 (3811012) 3811012..3812565 + 1554 WP_044699371.1 EAL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3807876..3808907 1031


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T247427 WP_002892050.1 NZ_CP098330:3807524-3807742 [Citrobacter freundii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT247427 WP_003021733.1 NZ_CP098330:3807122-3807496 [Citrobacter freundii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References