247422

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 880773..881427 Replicon chromosome
Accession NZ_CP098330
Organism Citrobacter freundii strain 59174

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag NB664_RS04360 Protein ID WP_003026936.1
Coordinates 881020..881427 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag NB664_RS04355 Protein ID WP_003026938.1
Coordinates 880773..881039 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB664_RS04330 (875974) 875974..877407 - 1434 WP_044700805.1 6-phospho-beta-glucosidase BglA -
NB664_RS04335 (877528) 877528..878256 - 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
NB664_RS04340 (878309) 878309..878620 + 312 WP_044700802.1 N(4)-acetylcytidine aminohydrolase -
NB664_RS04345 (878783) 878783..879442 + 660 WP_003838267.1 hemolysin III family protein -
NB664_RS04350 (879536) 879536..880516 - 981 WP_003026944.1 tRNA-modifying protein YgfZ -
NB664_RS04355 (880773) 880773..881039 + 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
NB664_RS04360 (881020) 881020..881427 + 408 WP_003026936.1 protein YgfX Toxin
NB664_RS04365 (881472) 881472..881993 - 522 WP_003026933.1 flavodoxin FldB -
NB664_RS04370 (882107) 882107..883003 + 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
NB664_RS04375 (883027) 883027..883740 + 714 WP_003026923.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NB664_RS04380 (883746) 883746..885479 + 1734 WP_044700800.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T247422 WP_003026936.1 NZ_CP098330:881020-881427 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT247422 WP_003026938.1 NZ_CP098330:880773-881039 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References