Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 284441..285072 Replicon chromosome
Accession NZ_CP098330
Organism Citrobacter freundii strain 59174

Toxin (Protein)


Gene name hicA Uniprot ID A0A0J1MPQ6
Locus tag NB664_RS01325 Protein ID WP_003837806.1
Coordinates 284441..284716 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1MMS0
Locus tag NB664_RS01330 Protein ID WP_003837808.1
Coordinates 284713..285072 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB664_RS01315 280492..283239 + 2748 WP_044701369.1 ribosome-associated ATPase/putative transporter RbbA -
NB664_RS01320 283239..284363 + 1125 WP_003837801.1 ABC transporter permease -
NB664_RS01325 284441..284716 + 276 WP_003837806.1 type II toxin-antitoxin system HicA family toxin Toxin
NB664_RS01330 284713..285072 + 360 WP_003837808.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NB664_RS01335 285183..285584 - 402 WP_003023387.1 nickel-responsive transcriptional regulator NikR -
NB664_RS01340 285634..286212 - 579 WP_003837810.1 4'-phosphopantetheinyl transferase AcpT -
NB664_RS01345 286275..287324 - 1050 WP_003023393.1 AI-2E family transporter -
NB664_RS01350 287458..288675 + 1218 WP_003846164.1 MFS transporter -
NB664_RS01355 288679..289236 - 558 WP_003837816.1 DcrB family lipoprotein -
NB664_RS01360 289309..289974 - 666 WP_044701371.1 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10210.88 Da        Isoelectric Point: 10.7228

>T247420 WP_003837806.1 NZ_CP098330:284441-284716 [Citrobacter freundii]
MKEKVLSLRKKQKNTLDQLFKAPTPQGIKWSEIESLIKALGGEIKEGRGSRCKFLLNKSIASFHRPHPSPDTDKGAVENV
RDWLTSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13198.98 Da        Isoelectric Point: 4.5462

>AT247420 WP_003837808.1 NZ_CP098330:284713-285072 [Citrobacter freundii]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGEISLREYLDDCSAAGIEPYANPEKLKT
FTLRYPESFGERLSFAAAEEQVSVNTWIIETLSKSLKQA

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MPQ6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MMS0

References