Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09907-MazE
Location 7958..8559 Replicon plasmid p2
Accession NZ_CP098329
Organism Lactiplantibacillus plantarum strain HOM3204

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag LGV77_RS15580 Protein ID WP_063486515.1
Coordinates 7958..8302 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID Q684P2
Locus tag LGV77_RS15585 Protein ID WP_003643337.1
Coordinates 8296..8559 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGV77_RS15565 (LGV77_15485) 3564..3653 + 90 Protein_3 IS30 family transposase -
LGV77_RS15570 (LGV77_15490) 3695..4162 - 468 WP_042253884.1 DNA starvation/stationary phase protection protein -
LGV77_RS15575 (LGV77_15495) 5304..7601 - 2298 WP_014271901.1 DUF1906 domain-containing protein -
LGV77_RS15580 (LGV77_15500) 7958..8302 - 345 WP_063486515.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LGV77_RS15585 (LGV77_15505) 8296..8559 - 264 WP_003643337.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LGV77_RS15590 (LGV77_15510) 8645..8947 + 303 Protein_8 site-specific integrase -
LGV77_RS15595 (LGV77_15515) 9307..10863 + 1557 WP_054736640.1 reverse transcriptase/maturase family protein -
LGV77_RS15600 (LGV77_15520) 11333..11686 + 354 WP_021730116.1 plasmid mobilization relaxosome protein MobC -
LGV77_RS15605 (LGV77_15525) 11668..12837 + 1170 WP_105450236.1 relaxase/mobilization nuclease domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..17060 17060


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-101)

Antitoxin

Antitoxin PemI-like

(8-85)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13068.91 Da        Isoelectric Point: 6.4782

>T247418 WP_063486515.1 NZ_CP098329:c8302-7958 [Lactiplantibacillus plantarum]
MVNQGDIFYVNFNPSRGHEQMNKRPAIALSNDLVCQTSNMTIVAPISSTKRNFPMYHRLTSSQTVYGKVLLDQTIALDLR
ARHVTDETIVDHVSREELEEIITLYKLLFSIDDK

Download         Length: 345 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10141.51 Da        Isoelectric Point: 6.4708

>AT247418 WP_003643337.1 NZ_CP098329:c8559-8296 [Lactiplantibacillus plantarum]
MELIKEQTRLAKWGNSKAARIPSQIIKQLKLDDNQDMTITIENGSIVLTPIKKNPTNIHELFKDWKDDGKRDHELDWGKS
EGNELQW

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6L4ZZT2

References