Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2295959..2297521 Replicon chromosome
Accession NZ_CP098325
Organism Leclercia adecarboxylata strain kcgeb_e1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NB069_RS11060 Protein ID WP_250589390.1
Coordinates 2295959..2297266 (-) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NB069_RS11065 Protein ID WP_250589391.1
Coordinates 2297270..2297521 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB069_RS11045 (NB069_11045) 2291472..2292653 - 1182 WP_250589387.1 PLP-dependent aminotransferase family protein -
NB069_RS11050 (NB069_11050) 2292787..2294781 - 1995 WP_250589388.1 TonB-dependent receptor -
NB069_RS11055 (NB069_11055) 2294792..2295853 - 1062 WP_250589389.1 YncE family protein -
NB069_RS11060 (NB069_11060) 2295959..2297266 - 1308 WP_250589390.1 type II toxin-antitoxin system HipA family toxin Toxin
NB069_RS11065 (NB069_11065) 2297270..2297521 - 252 WP_250589391.1 helix-turn-helix domain-containing protein Antitoxin
NB069_RS11070 (NB069_11070) 2298332..2302123 + 3792 WP_250589392.1 glycosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(151-397)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 48286.85 Da        Isoelectric Point: 7.8336

>T247411 WP_250589390.1 NZ_CP098325:c2297266-2295959 [Leclercia adecarboxylata]
MRAQRLTVAMNGDIVGTLHRDGSGAMSFEYAPEWLAEPGARAISLSLPLQHGRIRGKQVFNFFSNLLPDSEAIIARMQAR
FQVETAHPFDLLASVGRDCVGAIQLYPPGLDIPPVMDIVAEPLDDKQIAALLEGYQMAPLGMTEEDADFRISLAGAQEKT
ALLWYQNRWQRPLGSTPTSHIFKLPIGRIEQNNIDLSESCENEWLCLRIAKAFGFPVAHAEMATFRRKKVLIIERFDRRW
ARSGWLMRLPQEDFCQALGVSPALKYESHGGPGIAEAMKLLLGSRLAGQDREMFFKAQILFWMLAAIDGHGKNFSLFIEA
DSSFRMAPLYDVISAFPLFEAGSIPAKKAKMAMALQGKNRQYHFAMIQPRHFISTAAHAGFSQETALKLMKEMASRTGDV
IATVTAELPADFPQQISGAIFRGLASQAAKIGRME

Download         Length: 1308 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9288.54 Da        Isoelectric Point: 8.7075

>AT247411 WP_250589391.1 NZ_CP098325:c2297521-2297270 [Leclercia adecarboxylata]
MKVTSAGALAQAVRDQRKVNKLTQSETAEQVGIKQTTVSDFENRPESTKLETLFKILSALDLELHVVKRGSTLPDTSTWT
KEW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References