Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 59337..59999 Replicon chromosome
Accession NZ_CP098325
Organism Leclercia adecarboxylata strain kcgeb_e1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NB069_RS00305 Protein ID WP_250586824.1
Coordinates 59601..59999 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NB069_RS00300 Protein ID WP_250586822.1
Coordinates 59337..59597 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB069_RS00270 (NB069_00270) 54357..54671 - 315 WP_039030206.1 PTS sugar transporter subunit IIB -
NB069_RS00275 (NB069_00275) 54966..55913 + 948 WP_250586812.1 LacI family DNA-binding transcriptional regulator -
NB069_RS00280 (NB069_00280) 55948..56244 - 297 WP_250586814.1 YicS family protein -
NB069_RS00285 (NB069_00285) 56566..56985 + 420 WP_250586816.1 GNAT family N-acetyltransferase -
NB069_RS00290 (NB069_00290) 56982..57641 - 660 WP_250586818.1 TetR/AcrR family transcriptional regulator -
NB069_RS00295 (NB069_00295) 57720..59225 + 1506 WP_250586820.1 MDR family MFS transporter -
NB069_RS00300 (NB069_00300) 59337..59597 + 261 WP_250586822.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NB069_RS00305 (NB069_00305) 59601..59999 + 399 WP_250586824.1 type II toxin-antitoxin system VapC family toxin Toxin
NB069_RS00310 (NB069_00310) 60168..60971 + 804 WP_250586826.1 lipoprotein NlpA -
NB069_RS00315 (NB069_00315) 61110..61889 + 780 WP_250586828.1 MBL fold metallo-hydrolase -
NB069_RS00320 (NB069_00320) 61915..62883 + 969 WP_250586830.1 helix-turn-helix domain-containing protein -
NB069_RS00325 (NB069_00325) 62897..63985 - 1089 WP_250586832.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 6.1255

>T247406 WP_250586824.1 NZ_CP098325:59601-59999 [Leclercia adecarboxylata]
MLHMLDTNIVSHLVRQHPSVVNHYSQIAPEDMCISSVTEAELLYGVAKKQSHALHETISAFLKTITICDWDSDAAAIYGK
LRADMEKRGKVMGDLDQLIAAHALSRGTTIVTNDRAFGMVQELKVEDWTTAA

Download         Length: 399 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10310.62 Da        Isoelectric Point: 8.5940

>AT247406 WP_250586822.1 NZ_CP098325:59337-59597 [Leclercia adecarboxylata]
MERKAKVIKKGRNQAVILPDEFAFDTDSVYIRRDEEGNVVLRAMSEKERHREHFLRLLRQTHFPDSFLSKEERNQSYTTR
DPFEGL

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References