Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/Txe-RelB
Location 423829..424336 Replicon chromosome
Accession NZ_CP098324
Organism Rickettsia conorii subsp. raoultii strain BIME

Toxin (Protein)


Gene name relB Uniprot ID -
Locus tag NBT09_RS02315 Protein ID WP_064462994.1
Coordinates 424073..424336 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID H8K421
Locus tag NBT09_RS02310 Protein ID WP_014391803.1
Coordinates 423829..424080 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBT09_RS02275 (NBT09_02275) 418997..420064 - 1068 WP_250720035.1 alanine racemase -
NBT09_RS02280 (NBT09_02280) 420131..420349 - 219 WP_232218745.1 palindromic element RPE1 domain-containing protein -
NBT09_RS02285 (NBT09_02285) 420380..420715 - 336 Protein_453 ribose-phosphate diphosphokinase -
NBT09_RS02290 (NBT09_02290) 420782..421081 - 300 WP_064463000.1 ribose-phosphate pyrophosphokinase-like domain-containing protein -
NBT09_RS02295 (NBT09_02295) 421306..421905 - 600 WP_064462998.1 phospholipid-binding protein MlaC -
NBT09_RS02300 (NBT09_02300) 421925..422680 - 756 WP_250720037.1 VacJ family lipoprotein -
NBT09_RS02305 (NBT09_02305) 422685..423689 - 1005 WP_250720040.1 methyltransferase domain-containing protein -
NBT09_RS02310 (NBT09_02310) 423829..424080 + 252 WP_014391803.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NBT09_RS02315 (NBT09_02315) 424073..424336 + 264 WP_064462994.1 Txe/YoeB family addiction module toxin Toxin
NBT09_RS02320 (NBT09_02320) 424396..425601 + 1206 WP_064462992.1 pyridoxal phosphate-dependent aminotransferase -
NBT09_RS02325 (NBT09_02325) 425752..426408 + 657 WP_064462990.1 lysophospholipid acyltransferase family protein -
NBT09_RS02330 (NBT09_02330) 426405..427799 + 1395 WP_064462988.1 lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase -
NBT09_RS02335 (NBT09_02335) 427820..428161 - 342 WP_250720042.1 hypothetical protein -
NBT09_RS02340 (NBT09_02340) 428206..428835 - 630 WP_250720045.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10571.43 Da        Isoelectric Point: 10.1250

>T247405 WP_064462994.1 NZ_CP098324:424073-424336 [Rickettsia conorii subsp. raoultii]
MIEIEWTLEAAEDLAYWKKYDIKKYERIKLLIKNIQEAPFTGIGKPKPLKHILSGLWSRRINHEHRLIYSVNTKQIIIYN
CRFHYKN

Download         Length: 264 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9521.77 Da        Isoelectric Point: 9.4884

>AT247405 WP_014391803.1 NZ_CP098324:423829-424080 [Rickettsia conorii subsp. raoultii]
MNSISGTSFRKNLSSVLNTVENDHVPYLIKRKNHKNIILLTEEEYESTKETLYLLSNPANANRIKKSIEQAKRGEFAKVN
LDD

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0C2M0P5

References