Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2815096..2816939 Replicon chromosome
Accession NZ_CP098322
Organism Burkholderia gladioli strain BK04

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag NAL90_RS30340 Protein ID WP_250805883.1
Coordinates 2815096..2816061 (+) Length 322 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag NAL90_RS30345 Protein ID WP_013689908.1
Coordinates 2816058..2816939 (+) Length 294 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAL90_RS30305 (NAL90_30295) 2810405..2811484 - 1080 WP_250804966.1 porin -
NAL90_RS30310 (NAL90_30300) 2811594..2811884 + 291 WP_250804967.1 hypothetical protein -
NAL90_RS30315 (NAL90_30305) 2811899..2812216 + 318 WP_013689902.1 non-heme iron oxygenase ferredoxin subunit -
NAL90_RS30320 (NAL90_30310) 2812219..2812530 + 312 WP_013689903.1 hypothetical protein -
NAL90_RS30325 (NAL90_30315) 2812572..2813681 + 1110 WP_250804968.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
NAL90_RS30330 (NAL90_30320) 2813674..2814444 + 771 WP_250804969.1 SDR family oxidoreductase -
NAL90_RS30335 (NAL90_30325) 2814543..2815070 + 528 WP_036038832.1 cupin domain-containing protein -
NAL90_RS30340 (NAL90_30330) 2815096..2816061 + 966 WP_250805883.1 alpha/beta fold hydrolase Toxin
NAL90_RS30345 (NAL90_30335) 2816058..2816939 + 882 WP_013689908.1 IclR family transcriptional regulator Antitoxin
NAL90_RS30350 (NAL90_30340) 2816936..2817733 + 798 WP_096750801.1 SDR family oxidoreductase -
NAL90_RS30355 (NAL90_30345) 2817726..2819399 + 1674 WP_047838646.1 thiamine pyrophosphate-binding protein -
NAL90_RS30360 (NAL90_30350) 2819392..2820225 + 834 WP_155636871.1 aspartate dehydrogenase -
NAL90_RS30365 (NAL90_30355) 2820302..2821792 + 1491 WP_250804970.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(66-304)

Antitoxin

Transcription regulator IclR, C-terminal

(151-274)


Sequences

Toxin        


Download         Length: 322 a.a.        Molecular weight: 32767.25 Da        Isoelectric Point: 7.0329

>T247402 WP_250805883.1 NZ_CP098322:2815096-2816061 [Burkholderia gladioli]
MSEIDPRGAEAEAGPDAALAARLGQFPARRIAIREAGLIGWRESGPVEGAGDSTARAAAGERALPVVLLHGIGSGAASWL
AQLDTLGASRRVLAWDAPGYGESTPVAPASPLAADYAASLAGWLDALAIERCVLVGHSLGAIVAGAFARRHAGRLAGLLL
VSPAAGYGAAPAATRDERRDARLAMLAALGPAGLAEQRSANMLSAHAGEAARAWVRRVMAQVKPAGYTQATHLLANADLA
ADLAAWRAMTDAAGAARVEVMVGAEDGITPPNACERLAAAAGVALRIVPRAGHAGYVEAPERYSALIGAFCARCDESWRQ
A

Download         Length: 966 bp

Antitoxin


Download         Length: 294 a.a.        Molecular weight: 31787.20 Da        Isoelectric Point: 6.5132

>AT247402 WP_013689908.1 NZ_CP098322:2816058-2816939 [Burkholderia gladioli]
MNPTQLALRSEPADSGAPEADAANGAYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLER
ADKDRNYRLGVAVLRLGFEYLSSLELTDLGLPVIEGLREATGFTTHIVIRDGRDVVFVAKAQSAAPAFSSIRVNVGTRLP
AHATTHGHVLMGDLSEAELRALYPERQLERATRATPDSLEALLALVREDAARGYGISNSSFERGISVVTAPVRNDTQRIV
AAVTVTVPKPEIDAALIADGLVEKVVRAANELSRRLNYRSDDENSYLKALGLR

Download         Length: 882 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References