Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 55913..56555 Replicon chromosome
Accession NZ_CP098322
Organism Burkholderia gladioli strain BK04

Toxin (Protein)


Gene name vapC Uniprot ID F2LQ48
Locus tag NAL90_RS18915 Protein ID WP_013690721.1
Coordinates 55913..56335 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A808W4F3
Locus tag NAL90_RS18920 Protein ID WP_036033948.1
Coordinates 56322..56555 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAL90_RS18895 (NAL90_18890) 51713..53086 + 1374 WP_250805264.1 L-fucose:H+ symporter permease -
NAL90_RS18900 (NAL90_18895) 53089..54171 + 1083 WP_250805266.1 aldose 1-epimerase family protein -
NAL90_RS18905 (NAL90_18900) 54191..54961 - 771 WP_103692576.1 DNA-binding transcriptional repressor DeoR -
NAL90_RS18910 (NAL90_18905) 55111..55791 + 681 WP_250805269.1 deoxyribose-phosphate aldolase -
NAL90_RS18915 (NAL90_18910) 55913..56335 - 423 WP_013690721.1 type II toxin-antitoxin system VapC family toxin Toxin
NAL90_RS18920 (NAL90_18915) 56322..56555 - 234 WP_036033948.1 DNA-binding protein Antitoxin
NAL90_RS18925 (NAL90_18920) 56871..57860 - 990 WP_105850350.1 LysR substrate-binding domain-containing protein -
NAL90_RS18930 (NAL90_18925) 58479..60212 + 1734 WP_223996944.1 AMP-binding protein -
NAL90_RS18935 (NAL90_18930) 60337..60585 + 249 WP_013690725.1 acyl carrier protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15649.91 Da        Isoelectric Point: 8.5438

>T247400 WP_013690721.1 NZ_CP098322:c56335-55913 [Burkholderia gladioli]
MYLIDTNVVSEVRKRDRADKGVMAFFRQAARDDAGLYLSVVTVGELRRGVEIIRHRGDESQATRLANWLDGVLREFAANI
LVVDKEIGQMWGYLRVPRSEHSLDKVIAATALIHDLTVVTRNVDDFAGTGARVLNPFKGP

Download         Length: 423 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8484.61 Da        Isoelectric Point: 5.5741

>AT247400 WP_036033948.1 NZ_CP098322:c56555-56322 [Burkholderia gladioli]
MANLLVRNVDEMLVQILRERAAAHGHSAEAEHRAILARALREPQRKTFAQVLMGMPNVGSDADFARVDDGEAANVFD

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A833Q1H0

Antitoxin

Source ID Structure
AlphaFold DB A0A808W4F3

References