Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3104897..3106174 Replicon chromosome
Accession NZ_CP098321
Organism Burkholderia gladioli strain BK04

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NAL90_RS13705 Protein ID WP_186116226.1
Coordinates 3104897..3105481 (-) Length 195 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A808W933
Locus tag NAL90_RS13710 Protein ID WP_036049935.1
Coordinates 3105584..3106174 (-) Length 197 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAL90_RS13675 (NAL90_13670) 3100273..3100830 + 558 WP_244128802.1 DUF302 domain-containing protein -
NAL90_RS13680 (NAL90_13675) 3100955..3101917 - 963 WP_186237903.1 AraC family transcriptional regulator -
NAL90_RS34695 3102111..3102863 - 753 WP_284709516.1 lytic transglycosylase domain-containing protein -
NAL90_RS13695 (NAL90_13690) 3103268..3104005 - 738 WP_250802813.1 hypothetical protein -
NAL90_RS13705 (NAL90_13700) 3104897..3105481 - 585 WP_186116226.1 HD domain-containing protein Toxin
NAL90_RS13710 (NAL90_13705) 3105584..3106174 - 591 WP_036049935.1 helix-turn-helix transcriptional regulator Antitoxin
NAL90_RS13715 (NAL90_13710) 3106332..3106595 - 264 WP_013698802.1 PAAR domain-containing protein -
NAL90_RS13720 (NAL90_13715) 3106662..3107096 - 435 WP_250802814.1 hypothetical protein -
NAL90_RS13725 (NAL90_13720) 3107140..3109155 - 2016 WP_250802815.1 sodium:solute symporter family protein -
NAL90_RS13730 (NAL90_13725) 3109149..3109586 - 438 WP_250802816.1 DUF4212 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-171)

Antitoxin

Cro/C1-type helix-turn-helix domain

(27-73)


Sequences

Toxin        


Download         Length: 195 a.a.        Molecular weight: 21497.24 Da        Isoelectric Point: 5.0097

>T247399 WP_186116226.1 NZ_CP098321:c3105481-3104897 [Burkholderia gladioli]
MDDALIDARLDFLRGCERLKDVLRSGHTSGGRRESTAEHSWRLALMAMVLMDQLGEVDPGRVLELCLVHDLGEALGGDVP
APEQAPGSDKDAAERRDLLRLGDALDAPMRERIVALWDEYARAATPEARAVKALDKIETILQHTQGENPPDFDYAFNLAY
GQAHTRKVPALQRFRERLDEATRERMARAGGPSG

Download         Length: 585 bp

Antitoxin


Download         Length: 197 a.a.        Molecular weight: 21473.34 Da        Isoelectric Point: 8.7063

>AT247399 WP_036049935.1 NZ_CP098321:c3106174-3105584 [Burkholderia gladioli]
MKPISSNQATTTSLPPSALACSPGASLRRWRTLRRIKQEHAAALFGVSQSTISRWEAGTQAVSHEELRRIEACLSARLDS
AADRALERLVSHHTRPVHLVCDLTHRLLACSAPRAAEFAAPLSSLMGASLWPFATAEIVAREQSLRDAGWQDHPAPSIEF
DTGSNDSPQVPIRASRCRWTRFTLSDGTLARLVETL

Download         Length: 591 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A808W933

References