Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2383410..2384186 Replicon chromosome
Accession NZ_CP098257
Organism Staphylococcus aureus strain M4

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag NB631_RS11620 Protein ID WP_000031108.1
Coordinates 2384034..2384186 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag NB631_RS11615 Protein ID WP_001251219.1
Coordinates 2383410..2384009 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB631_RS11595 (NB631_11605) 2379326..2380783 + 1458 WP_000649898.1 ABC transporter permease subunit -
NB631_RS11600 (NB631_11610) 2380776..2381498 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
NB631_RS11605 (NB631_11615) 2381649..2382776 + 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
NB631_RS11610 (NB631_11620) 2382781..2383251 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NB631_RS11615 (NB631_11625) 2383410..2384009 + 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
NB631_RS11620 (NB631_11630) 2384034..2384186 + 153 WP_000031108.1 SAS053 family protein Toxin
NB631_RS11625 (NB631_11635) 2384787..2385182 + 396 WP_000901019.1 hypothetical protein -
NB631_RS11630 (NB631_11640) 2385378..2386763 + 1386 WP_000116227.1 class II fumarate hydratase -
NB631_RS11635 (NB631_11645) 2387218..2388039 - 822 WP_000669380.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T247397 WP_000031108.1 NZ_CP098257:2384034-2384186 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT247397 WP_001251219.1 NZ_CP098257:2383410-2384009 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References