Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2195033..2195547 Replicon chromosome
Accession NZ_CP098255
Organism Staphylococcus aureus strain N4

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag NB630_RS10540 Protein ID WP_000581791.1
Coordinates 2195338..2195547 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag NB630_RS10535 Protein ID WP_000138934.1
Coordinates 2195033..2195326 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB630_RS10510 (NB630_10510) 2190496..2191137 + 642 WP_000483150.1 thiamine phosphate synthase -
NB630_RS10515 (NB630_10515) 2191223..2192095 + 873 WP_000725802.1 membrane protein insertase YidC -
NB630_RS10520 (NB630_10520) 2192252..2192551 - 300 WP_001793952.1 hypothetical protein -
NB630_RS10525 (NB630_10525) 2192708..2193355 - 648 WP_001187612.1 HD domain-containing protein -
NB630_RS10530 (NB630_10530) 2193383..2194867 - 1485 WP_000571560.1 cardiolipin synthase -
NB630_RS10535 (NB630_10535) 2195033..2195326 + 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
NB630_RS10540 (NB630_10540) 2195338..2195547 + 210 WP_000581791.1 heavy metal-associated domain-containing protein Toxin
NB630_RS10545 (NB630_10545) 2195675..2195812 + 138 WP_000828354.1 Lmo0850 family protein -
NB630_RS10550 (NB630_10550) 2196224..2196907 + 684 Protein_2074 transposase -
NB630_RS10555 (NB630_10555) 2197068..2198270 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
NB630_RS10560 (NB630_10560) 2198588..2199658 + 1071 WP_000159638.1 D-alanine--D-alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T247381 WP_000581791.1 NZ_CP098255:2195338-2195547 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT247381 WP_000138934.1 NZ_CP098255:2195033-2195326 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References