Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 428438..429195 Replicon chromosome
Accession NC_014121
Organism Enterobacter cloacae subsp. cloacae ATCC 13047

Toxin (Protein)


Gene name tacT Uniprot ID A0A1D8JMF4
Locus tag ECL_RS02025 Protein ID WP_044159004.1
Coordinates 428713..429195 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A1D8JMH3
Locus tag ECL_RS02020 Protein ID WP_007372584.1
Coordinates 428438..428722 (+) Length 95 a.a.

Genomic Context

ECL_RS02000ECL_RS02005ECL_RS02010ECL_RS02015ECL_RS02020ECL_RS02025ECL_RS02030ECL_RS02035ECL_RS02040ECL_RS02045
Location: 423831..424553 (723 bp)
Type: Others
Protein ID: WP_013095151.1
Location: 424571..426582 (2012 bp)
Type: Others
Protein ID: Protein_386
Location: 427215..427706 (492 bp)
Type: Others
Protein ID: WP_007372582.1
Location: 427782..428282 (501 bp)
Type: Others
Protein ID: WP_007372583.1
Location: 428438..428722 (285 bp)
Type: Antitoxin
Protein ID: WP_007372584.1
Location: 428713..429195 (483 bp)
Type: Toxin
Protein ID: WP_044159004.1
Location: 429428..430714 (1287 bp)
Type: Others
Protein ID: WP_013095156.1
Location: 430716..431159 (444 bp)
Type: Others
Protein ID: WP_007372587.1
Location: 431179..432852 (1674 bp)
Type: Others
Protein ID: WP_013095157.1
Location: 432855..434135 (1281 bp)
Type: Others
Protein ID: WP_176682058.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ECL_RS02000423831..424553+723WP_013095151.1TIGR03761 family integrating conjugative element protein-
ECL_RS02005424571..426582+2012Protein_386DNA topoisomerase III-
ECL_RS02010427215..427706+492WP_007372582.1DUF3577 domain-containing protein-
ECL_RS02015427782..428282+501WP_007372583.1single-stranded DNA-binding protein-
ECL_RS02020428438..428722+285WP_007372584.1DUF1778 domain-containing proteinAntitoxin
ECL_RS02025428713..429195+483WP_044159004.1GNAT family N-acetyltransferaseToxin
ECL_RS02030429428..430714+1287WP_013095156.1TcpQ domain-containing protein-
ECL_RS02035430716..431159+444WP_007372587.1type IV pilus biogenesis protein PilM-
ECL_RS02040431179..432852+1674WP_013095157.1PilN family type IVB pilus formation outer membrane protein-
ECL_RS02045432855..434135+1281WP_176682058.1type 4b pilus protein PilO2-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegrative and Conjugative Element--416311..525347109036


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(39-146)

Antitoxin

Vibrio phage ICP1, Orf50

(1-93)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17693.32 Da        Isoelectric Point: 6.9570

>T24738 WP_044159004.1 NC_014121:428713-429195 [Enterobacter cloacae subsp. cloacae ATCC 13047]
MEINVTAPALLTEEHVLHSFDCGNAVLDDWLRRRALKNQHLNASRTFVICPEGTACVVGYYSLATGSVSHVDLSRSLRQN
MPDPVPVVLLGRLAVDVSTQGNNFGKWLLNDAVMRVSNLADQVGIKAIMVHAIDERAKAFYEYFGFVQSPVAANTLFYKI

Download         Length: 483 bp

>T24738 NC_014121:428713-429195 [Enterobacter cloacae subsp. cloacae ATCC 13047]
ATGGAAATAAATGTCACTGCGCCTGCTTTACTGACAGAGGAGCATGTTCTTCATTCGTTCGATTGCGGGAATGCGGTACT
TGATGACTGGCTTCGCCGGCGTGCGTTGAAGAATCAGCATCTTAATGCTTCCCGGACATTCGTCATCTGTCCTGAAGGTA
CTGCGTGTGTAGTGGGTTATTATTCCCTTGCGACGGGCTCAGTTAGTCATGTCGACTTGAGTCGTAGTCTGCGACAGAAT
ATGCCCGATCCCGTACCGGTTGTTTTGCTGGGCCGCCTTGCAGTCGATGTATCCACTCAGGGCAATAACTTCGGGAAATG
GTTGCTGAATGATGCTGTGATGCGCGTATCGAATCTGGCGGATCAGGTCGGCATCAAGGCTATCATGGTGCATGCAATTG
ATGAGCGGGCTAAAGCGTTCTATGAATACTTTGGTTTTGTGCAGTCACCGGTTGCGGCTAACACGCTTTTCTACAAAATA
TAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11078.63 Da        Isoelectric Point: 8.5684

>AT24738 WP_007372584.1 NC_014121:428438-428722 [Enterobacter cloacae subsp. cloacae ATCC 13047]
MQTPVRKSVRDKQINIRATDEERAVIDYAASLVNKNRTDFIIERAVHEAQNIILDQRVFVLDDARYQAFIRQLEAPVQNV
EGRQRLMDVKPEWK

Download         Length: 285 bp

>AT24738 NC_014121:428438-428722 [Enterobacter cloacae subsp. cloacae ATCC 13047]
ATGCAAACTCCAGTCCGTAAATCCGTCCGTGACAAGCAAATCAATATCCGCGCCACGGATGAAGAACGTGCGGTGATTGA
TTACGCTGCGAGTCTGGTTAATAAAAACCGTACTGATTTCATCATTGAAAGGGCTGTGCATGAGGCCCAGAACATCATTC
TGGACCAGCGTGTGTTCGTTCTTGATGATGCCCGTTACCAGGCGTTCATCAGGCAGCTTGAAGCCCCTGTGCAGAATGTT
GAAGGTCGTCAGCGACTGATGGATGTAAAACCTGAATGGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1D8JMF4

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1D8JMH3

References