Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2383419..2384195 Replicon chromosome
Accession NZ_CP098253
Organism Staphylococcus aureus strain M0

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag NB629_RS11620 Protein ID WP_000031108.1
Coordinates 2384043..2384195 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag NB629_RS11615 Protein ID WP_001251219.1
Coordinates 2383419..2384018 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB629_RS11595 (NB629_11595) 2379335..2380792 + 1458 WP_000649898.1 ABC transporter permease subunit -
NB629_RS11600 (NB629_11600) 2380785..2381507 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
NB629_RS11605 (NB629_11605) 2381658..2382785 + 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
NB629_RS11610 (NB629_11610) 2382790..2383260 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NB629_RS11615 (NB629_11615) 2383419..2384018 + 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
NB629_RS11620 (NB629_11620) 2384043..2384195 + 153 WP_000031108.1 SAS053 family protein Toxin
NB629_RS11625 (NB629_11625) 2384796..2385191 + 396 WP_000901019.1 hypothetical protein -
NB629_RS11630 (NB629_11630) 2385387..2386772 + 1386 WP_000116227.1 class II fumarate hydratase -
NB629_RS11635 (NB629_11635) 2387227..2388048 - 822 WP_000669380.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T247371 WP_000031108.1 NZ_CP098253:2384043-2384195 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT247371 WP_001251219.1 NZ_CP098253:2383419-2384018 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References