247370

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 2268470..2268999 Replicon chromosome
Accession NZ_CP098253
Organism Staphylococcus aureus strain M0

Toxin (Protein)


Gene name TscT Uniprot ID A0A0C6DV13
Locus tag NB629_RS10900 Protein ID WP_001103929.1
Coordinates 2268682..2268999 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag NB629_RS10895 Protein ID WP_001058486.1
Coordinates 2268470..2268679 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB629_RS10865 (NB629_10865) 2265145..2266317 - 1173 WP_000024832.1 tyrosine-type recombinase/integrase -
NB629_RS10870 (NB629_10870) 2266330..2266992 - 663 WP_001070979.1 helix-turn-helix transcriptional regulator -
NB629_RS10875 (NB629_10875) 2267146..2267358 + 213 WP_000448765.1 helix-turn-helix transcriptional regulator -
NB629_RS10880 (NB629_10880) 2267362..2268003 + 642 WP_000595329.1 phage repressor protein -
NB629_RS10885 (NB629_10885) 2268017..2268334 + 318 WP_000481972.1 helix-turn-helix domain-containing protein -
NB629_RS10890 (NB629_10890) 2268331..2268477 + 147 WP_000833313.1 hypothetical protein -
NB629_RS10895 (NB629_10895) 2268470..2268679 + 210 WP_001058486.1 hypothetical protein Antitoxin
NB629_RS10900 (NB629_10900) 2268682..2268999 + 318 WP_001103929.1 DUF1474 family protein Toxin
NB629_RS10905 (NB629_10905) 2269063..2269932 + 870 WP_001002839.1 primase alpha helix C-terminal domain-containing protein -
NB629_RS10910 (NB629_10910) 2269949..2271418 + 1470 WP_001834090.1 virulence-associated E family protein -
NB629_RS10915 (NB629_10915) 2271715..2272077 + 363 WP_001039171.1 hypothetical protein -
NB629_RS10920 (NB629_10920) 2272079..2272363 + 285 WP_000998182.1 hypothetical protein -
NB629_RS10925 (NB629_10925) 2272360..2273001 + 642 WP_038413070.1 pathogenicity island protein -
NB629_RS10930 (NB629_10930) 2273348..2273689 + 342 WP_001161492.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL 2263100..2287476 24376


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12666.19 Da        Isoelectric Point: 4.5462

>T247370 WP_001103929.1 NZ_CP098253:2268682-2268999 [Staphylococcus aureus]
MNWEIKDLICDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFDELIQKF
HELEKASSENFDEESDDAQKLKITE

Download         Length: 318 bp

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8252.31 Da        Isoelectric Point: 4.3718

>AT247370 WP_001058486.1 NZ_CP098253:2268470-2268679 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C6DV13

Antitoxin

Source ID Structure

References