Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 282883..283479 Replicon chromosome
Accession NC_014121
Organism Enterobacter cloacae subsp. cloacae ATCC 13047

Toxin (Protein)


Gene name PumA Uniprot ID A0A0M7H115
Locus tag ECL_RS01340 Protein ID WP_029882644.1
Coordinates 283177..283479 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A0F1AUP1
Locus tag ECL_RS01335 Protein ID WP_013095028.1
Coordinates 282883..283170 (-) Length 96 a.a.

Genomic Context

ECL_RS01330ECL_RS01345ECL_RS01335ECL_RS01340ECL_RS01350ECL_RS01355
Location: 281255..282886 (1632 bp)
Type: Others
Protein ID: WP_013095027.1
Location: 283677..284546 (870 bp)
Type: Others
Protein ID: WP_013095030.1
Location: 282883..283170 (288 bp)
Type: Antitoxin
Protein ID: WP_013095028.1
Location: 283177..283479 (303 bp)
Type: Toxin
Protein ID: WP_029882644.1
Location: 284614..285558 (945 bp)
Type: Others
Protein ID: WP_013095031.1
Location: 285651..287000 (1350 bp)
Type: Others
Protein ID: WP_013095032.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ECL_RS01330281255..282886+1632WP_013095027.1Na/Pi cotransporter family protein-
ECL_RS01335282883..283170-288WP_013095028.1putative addiction module antidote proteinAntitoxin
ECL_RS01340283177..283479-303WP_029882644.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ECL_RS01345283677..284546+870WP_013095030.123S rRNA pseudouridine(2604) synthase RluF-
ECL_RS01350284614..285558-945WP_013095031.1ketopantoate/pantoate/pantothenate transporter PanS-
ECL_RS01355285651..287000-1350WP_013095032.1lysine-sensitive aspartokinase 3-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-93)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11457.30 Da        Isoelectric Point: 9.7662

>T24737 WP_029882644.1 NC_014121:c283479-283177 [Enterobacter cloacae subsp. cloacae ATCC 13047]
MKEIVQTESFRRWEQNLKDRRARTIIASRLFRLANGLAGDIKPVGEGICELRIHFGPGYRIYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

>T24737 NC_014121:c283479-283177 [Enterobacter cloacae subsp. cloacae ATCC 13047]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAAGATCGGCGAGCAAGGACCATTATCGC
GTCCCGCCTCTTTCGGTTGGCAAATGGCTTAGCGGGCGACATAAAACCCGTGGGGGAAGGTATATGCGAGCTGAGGATCC
ACTTTGGTCCGGGCTACAGAATCTATTTTAAAGACCAGGGCAATTGCATCATCGTGCTGTTGTGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10070.62 Da        Isoelectric Point: 5.7807

>AT24737 WP_013095028.1 NC_014121:c283170-282883 [Enterobacter cloacae subsp. cloacae ATCC 13047]
MHKLTPYDPAIALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPAGD

Download         Length: 288 bp

>AT24737 NC_014121:c283170-282883 [Enterobacter cloacae subsp. cloacae ATCC 13047]
ATGCATAAATTAACACCCTACGATCCAGCCATCGCGTTGGTGGATGATGAGGAAATAGCCGTGTTTATGGCTGATGCATT
AGAAACCGGTGACTCAGCGTATATTGCTAAAGCTTTGGGCGTCATCGCGCGAGCGAAAGGGATGTCGACCATTTCACAGC
AAACTGGCCTGTCACGGGAACAACTGTACCGATCATTTAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGTCTTGGGCTCACAATCAAACCCGCCGGGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0M7H115

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0F1AUP1

References