Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1653167..1653750 Replicon chromosome
Accession NZ_CP098247
Organism Oxalobacter aliiformigenes strain BA2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NB636_RS07885 Protein ID WP_269281414.1
Coordinates 1653496..1653750 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NB636_RS07880 Protein ID WP_269281415.1
Coordinates 1653167..1653499 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB636_RS07865 (NB636_07830) 1649939..1650835 + 897 WP_269281421.1 radical SAM protein -
NB636_RS07870 (NB636_07835) 1651068..1652558 + 1491 WP_269281419.1 sodium/proline symporter PutP -
NB636_RS07875 (NB636_07840) 1652854..1653138 + 285 WP_269281417.1 hypothetical protein -
NB636_RS07880 (NB636_07845) 1653167..1653499 - 333 WP_269281415.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NB636_RS07885 (NB636_07850) 1653496..1653750 - 255 WP_269281414.1 type II toxin-antitoxin system HicA family toxin Toxin
NB636_RS07890 (NB636_07855) 1653954..1655036 - 1083 WP_269281412.1 porin -
NB636_RS07895 (NB636_07860) 1655218..1655400 - 183 WP_269281410.1 hypothetical protein -
NB636_RS07900 (NB636_07865) 1655403..1655759 - 357 WP_269281409.1 hypothetical protein -
NB636_RS07905 (NB636_07870) 1655770..1656450 - 681 WP_269281407.1 hypothetical protein -
NB636_RS07910 (NB636_07875) 1656842..1657315 - 474 WP_269281405.1 lysis system i-spanin subunit Rz -
NB636_RS07915 (NB636_07880) 1657339..1657500 - 162 WP_269281404.1 anaerobic ribonucleoside-triphosphate reductase -
NB636_RS07920 (NB636_07885) 1657448..1658014 - 567 WP_269281403.1 lysozyme -
NB636_RS07925 (NB636_07890) 1658011..1658331 - 321 WP_269281402.1 hypothetical protein -
NB636_RS07930 (NB636_07895) 1658294..1658572 - 279 WP_269281401.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1651068..1692245 41177


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(55-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9473.95 Da        Isoelectric Point: 10.0015

>T247356 WP_269281414.1 NZ_CP098247:c1653750-1653496 [Oxalobacter aliiformigenes]
MKRKYQITLEKIYSRPVNGSIKWADVESLLESLGVTIEEREGSRVGVVLFGVVKVFHRPHPSPDTDKGAIASIRKWLEEN
GVKP

Download         Length: 255 bp

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12275.08 Da        Isoelectric Point: 5.8506

>AT247356 WP_269281415.1 NZ_CP098247:c1653499-1653167 [Oxalobacter aliiformigenes]
MNNIMMIDGQKAVIQYDPDIEMFRGEFLNLSGGADFYASDIDGLKREGRQSLKVYLDMCREKGIEPYKSYSGRFNVRMSP
DLHAAIVCKAAAQGKSLNDLIVEAVTAYAK

Download         Length: 333 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References