Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1854210..1855687 Replicon chromosome
Accession NZ_CP098246
Organism Oxalobacter formigenes strain HOxSLD-2

Toxin (Protein)


Gene name HipA1 Uniprot ID C3X8C7
Locus tag NB644_RS08650 Protein ID WP_005879940.1
Coordinates 1854210..1855466 (-) Length 419 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag NB644_RS08655 Protein ID WP_005879938.1
Coordinates 1855463..1855687 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB644_RS08635 (NB644_08585) 1850975..1851460 - 486 WP_036602666.1 ESPR-type extended signal peptide-containing protein -
NB644_RS08640 (NB644_08590) 1852403..1853269 + 867 WP_005879944.1 hypothetical protein -
NB644_RS08645 (NB644_08595) 1853326..1854201 + 876 WP_005879942.1 hypothetical protein -
NB644_RS08650 (NB644_08600) 1854210..1855466 - 1257 WP_005879940.1 type II toxin-antitoxin system HipA family toxin Toxin
NB644_RS08655 (NB644_08605) 1855463..1855687 - 225 WP_005879938.1 helix-turn-helix domain-containing protein Antitoxin
NB644_RS08660 (NB644_08610) 1855876..1856253 - 378 WP_036602664.1 DUF1622 domain-containing protein -
NB644_RS08665 (NB644_08615) 1856495..1857163 + 669 WP_231284462.1 NAD(P)H-binding protein -
NB644_RS08670 (NB644_08620) 1857175..1857630 + 456 WP_036602661.1 pyridoxamine 5'-phosphate oxidase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(146-351)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-66)


Sequences

Toxin        


Download         Length: 419 a.a.        Molecular weight: 46365.63 Da        Isoelectric Point: 6.7525

>T247350 WP_005879940.1 NZ_CP098246:c1855466-1854210 [Oxalobacter formigenes]
MSRILDVYLHEKMAGTLAQNENGQLVFKYNSNYLDSNGMAISVSMPLRDEPYPDRIARPYFAGLLPDERARRRLAAVLGV
SDENVFGLLEIIGGECAGALSLLPQGQPLPDFSTGTVEVLDGKRLAELLDLLRQKPLLGGVEGIRLSLAGAQDKLAVCFI
DGQIFLPKNGLPTTHILKPFIEGLSGTVENEVFCMMLAGRVGLDAPVVSKGMAGNTGFILVERYDRVREENGRILRLHQE
DFCQALGVPPEIKYESEGGPGIASSQALIQNVTQRPAADRRAFQQRVIFHYLVGNADAHAKNYSLLYQGKTPVLAPVYDV
VCTDVYSLAKNMAMKIGERSLPDTIRLEDWQKMVPDTRVAKRILSDDLLRMANGIEIEADRLLEELNDQNLYHPVLKKIR
RTIGVRVRTIQKLMEKIA

Download         Length: 1257 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8124.44 Da        Isoelectric Point: 10.5957

>AT247350 WP_005879938.1 NZ_CP098246:c1855687-1855463 [Oxalobacter formigenes]
MTSVQNHIALGNLVRIERKRQKLTQEQLAALAGVGVRFLRELEKGKDSCRIGLAFSVMQTLGLSVDVSGRGDEK

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C3X8C7

Antitoxin

Source ID Structure

References