Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 505220..506697 Replicon chromosome
Accession NZ_CP098244
Organism Oxalobacter formigenes strain OxWR1

Toxin (Protein)


Gene name HipA1 Uniprot ID C3X8C7
Locus tag NB639_RS02165 Protein ID WP_005879940.1
Coordinates 505441..506697 (+) Length 419 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag NB639_RS02160 Protein ID WP_269307632.1
Coordinates 505220..505444 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB639_RS02140 (NB639_02140) 501645..503030 - 1386 WP_269307629.1 FAD-dependent oxidoreductase -
NB639_RS02145 (NB639_02145) 503277..503732 - 456 WP_269307631.1 pyridoxamine 5'-phosphate oxidase family protein -
NB639_RS02150 (NB639_02150) 503744..504412 - 669 WP_231284462.1 NAD(P)H-binding protein -
NB639_RS02155 (NB639_02155) 504654..505031 + 378 WP_036602664.1 DUF1622 domain-containing protein -
NB639_RS02160 (NB639_02160) 505220..505444 + 225 WP_269307632.1 helix-turn-helix domain-containing protein Antitoxin
NB639_RS02165 (NB639_02165) 505441..506697 + 1257 WP_005879940.1 type II toxin-antitoxin system HipA family toxin Toxin
NB639_RS02170 (NB639_02170) 506706..507581 - 876 WP_005879942.1 hypothetical protein -
NB639_RS02175 (NB639_02175) 507638..508504 - 867 WP_005879944.1 hypothetical protein -
NB639_RS02180 (NB639_02180) 509447..509932 + 486 WP_036602666.1 ESPR-type extended signal peptide-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(146-351)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-66)


Sequences

Toxin        


Download         Length: 419 a.a.        Molecular weight: 46365.63 Da        Isoelectric Point: 6.7525

>T247345 WP_005879940.1 NZ_CP098244:505441-506697 [Oxalobacter formigenes]
MSRILDVYLHEKMAGTLAQNENGQLVFKYNSNYLDSNGMAISVSMPLRDEPYPDRIARPYFAGLLPDERARRRLAAVLGV
SDENVFGLLEIIGGECAGALSLLPQGQPLPDFSTGTVEVLDGKRLAELLDLLRQKPLLGGVEGIRLSLAGAQDKLAVCFI
DGQIFLPKNGLPTTHILKPFIEGLSGTVENEVFCMMLAGRVGLDAPVVSKGMAGNTGFILVERYDRVREENGRILRLHQE
DFCQALGVPPEIKYESEGGPGIASSQALIQNVTQRPAADRRAFQQRVIFHYLVGNADAHAKNYSLLYQGKTPVLAPVYDV
VCTDVYSLAKNMAMKIGERSLPDTIRLEDWQKMVPDTRVAKRILSDDLLRMANGIEIEADRLLEELNDQNLYHPVLKKIR
RTIGVRVRTIQKLMEKIA

Download         Length: 1257 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8138.46 Da        Isoelectric Point: 10.5957

>AT247345 WP_269307632.1 NZ_CP098244:505220-505444 [Oxalobacter formigenes]
MTSVQNHIALGNLVRIERKRQKLTQEQLAALAGVGVRFLRELEKGKDSCRIGLAFSVMQTLGLSLDVSGRGDEK

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C3X8C7

Antitoxin

Source ID Structure

References