Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 44711..45222 Replicon chromosome
Accession NZ_CP098244
Organism Oxalobacter formigenes strain OxWR1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NB639_RS00215 Protein ID WP_269307865.1
Coordinates 45046..45222 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NB639_RS00210 Protein ID WP_269307488.1
Coordinates 44711..45046 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB639_RS00190 (NB639_00190) 40483..40785 - 303 WP_269307483.1 hypothetical protein -
NB639_RS00195 (NB639_00195) 41431..41730 + 300 WP_269307484.1 hypothetical protein -
NB639_RS00200 (NB639_00200) 41827..42555 - 729 WP_269307485.1 hypothetical protein -
NB639_RS00205 (NB639_00205) 43283..44080 - 798 WP_269307487.1 KilA-N domain-containing protein -
NB639_RS00210 (NB639_00210) 44711..45046 - 336 WP_269307488.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NB639_RS00215 (NB639_00215) 45046..45222 - 177 WP_269307865.1 type II toxin-antitoxin system HicA family toxin Toxin
NB639_RS00225 (NB639_00225) 45905..48286 + 2382 WP_269307489.1 ribonuclease R -
NB639_RS00230 (NB639_00230) 48318..49067 + 750 WP_005879369.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -
NB639_RS00235 (NB639_00235) 49134..49883 + 750 WP_269307490.1 serine O-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(2-50)

Antitoxin

Uncharacterised protein family HicB

(55-104)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6550.53 Da        Isoelectric Point: 6.4597

>T247343 WP_269307865.1 NZ_CP098244:c45222-45046 [Oxalobacter formigenes]
IEQLFLELGAFIEEREGSRVGVFLFGVVKVFHRPHPSPDTDKGAVTAIRKWLEENGVK

Download         Length: 177 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12406.16 Da        Isoelectric Point: 4.9048

>AT247343 WP_269307488.1 NZ_CP098244:c45046-44711 [Oxalobacter formigenes]
MNNLMTINDHKAVIQYDPEIEMFRGEFIGLAGGADFYASDIEGLKTEGAKSLEVYFDMCKERGIEPYKSFSGRFNVRMPP
ELHAQIVCAAAARGKSLNDLIVEAVTEFTKH

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References