Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4548777..4549274 Replicon chromosome
Accession NZ_CP098234
Organism Escherichia coli strain ZYB39

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag KFZ69_RS21950 Protein ID WP_001173343.1
Coordinates 4548777..4548950 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag KFZ69_RS21955 Protein ID WP_000398619.1
Coordinates 4548978..4549274 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ69_RS21940 (4545447) 4545447..4546904 + 1458 WP_275874760.1 dipeptide/tripeptide permease DtpC -
KFZ69_RS21945 (4547141) 4547141..4548658 + 1518 WP_001295087.1 lysine--tRNA ligase -
KFZ69_RS21950 (4548777) 4548777..4548950 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
KFZ69_RS21955 (4548978) 4548978..4549274 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
KFZ69_RS21960 (4549501) 4549501..4549773 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
KFZ69_RS21965 (4549986) 4549986..4553915 - 3930 WP_001542592.1 autotransporter outer membrane beta-barrel domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4537605..4572586 34981


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T247338 WP_001173343.1 NZ_CP098234:c4548950-4548777 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT247338 WP_000398619.1 NZ_CP098234:c4549274-4548978 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References