Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4353518..4354113 Replicon chromosome
Accession NZ_CP098234
Organism Escherichia coli strain ZYB39

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag KFZ69_RS21005 Protein ID WP_000239579.1
Coordinates 4353518..4353868 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag KFZ69_RS21010 Protein ID WP_001223208.1
Coordinates 4353862..4354113 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ69_RS20985 (4348794) 4348794..4349816 - 1023 WP_001355798.1 ABC transporter permease -
KFZ69_RS20990 (4349830) 4349830..4351332 - 1503 WP_000205791.1 sugar ABC transporter ATP-binding protein -
KFZ69_RS20995 (4351642) 4351642..4352598 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
KFZ69_RS21000 (4352908) 4352908..4353438 + 531 WP_000055075.1 inorganic diphosphatase -
KFZ69_RS21005 (4353518) 4353518..4353868 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
KFZ69_RS21010 (4353862) 4353862..4354113 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
KFZ69_RS21015 (4354325) 4354325..4354666 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
KFZ69_RS21020 (4354669) 4354669..4358448 - 3780 WP_000060896.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T247336 WP_000239579.1 NZ_CP098234:c4353868-4353518 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT247336 WP_001223208.1 NZ_CP098234:c4354113-4353862 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References