Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3569845..3570463 Replicon chromosome
Accession NZ_CP098234
Organism Escherichia coli strain ZYB39

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag KFZ69_RS17305 Protein ID WP_001291435.1
Coordinates 3570245..3570463 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag KFZ69_RS17300 Protein ID WP_000344800.1
Coordinates 3569845..3570219 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ69_RS17290 (3564934) 3564934..3566127 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KFZ69_RS17295 (3566150) 3566150..3569299 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
KFZ69_RS17300 (3569845) 3569845..3570219 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
KFZ69_RS17305 (3570245) 3570245..3570463 + 219 WP_001291435.1 HHA domain-containing protein Toxin
KFZ69_RS17310 (3570634) 3570634..3571185 + 552 WP_000102556.1 maltose O-acetyltransferase -
KFZ69_RS17315 (3571301) 3571301..3571771 + 471 WP_000136192.1 YlaC family protein -
KFZ69_RS17320 (3571935) 3571935..3573485 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
KFZ69_RS17325 (3573527) 3573527..3573880 - 354 WP_000878140.1 DUF1428 domain-containing protein -
KFZ69_RS17335 (3574259) 3574259..3574570 + 312 WP_000409911.1 MGMT family protein -
KFZ69_RS17340 (3574601) 3574601..3575173 - 573 WP_187225142.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T247332 WP_001291435.1 NZ_CP098234:3570245-3570463 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT247332 WP_000344800.1 NZ_CP098234:3569845-3570219 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References