Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2549709..2550347 Replicon chromosome
Accession NZ_CP098234
Organism Escherichia coli strain ZYB39

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag KFZ69_RS12290 Protein ID WP_000813794.1
Coordinates 2550171..2550347 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KFZ69_RS12285 Protein ID WP_001270286.1
Coordinates 2549709..2550125 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ69_RS12265 (2544861) 2544861..2545802 - 942 WP_275874720.1 ABC transporter permease -
KFZ69_RS12270 (2545803) 2545803..2546816 - 1014 WP_001542893.1 ABC transporter ATP-binding protein -
KFZ69_RS12275 (2546834) 2546834..2547979 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
KFZ69_RS12280 (2548224) 2548224..2549630 - 1407 WP_000760663.1 PLP-dependent aminotransferase family protein -
KFZ69_RS12285 (2549709) 2549709..2550125 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
KFZ69_RS12290 (2550171) 2550171..2550347 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
KFZ69_RS12295 (2550569) 2550569..2550799 + 231 WP_000494244.1 YncJ family protein -
KFZ69_RS12300 (2550891) 2550891..2552852 - 1962 WP_001442195.1 23S rRNA 5-hydroxycytidine C2501 synthase -
KFZ69_RS12305 (2552925) 2552925..2553461 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
KFZ69_RS12310 (2553553) 2553553..2554728 + 1176 WP_001583501.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2554768..2555916 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T247331 WP_000813794.1 NZ_CP098234:c2550347-2550171 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT247331 WP_001270286.1 NZ_CP098234:c2550125-2549709 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References