Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3344632..3345221 Replicon chromosome
Accession NC_014117
Organism Burkholderia sp. CCGE1002

Toxin (Protein)


Gene name hicA Uniprot ID D5W6F7
Locus tag BC1002_RS36300 Protein ID WP_013090886.1
Coordinates 3344632..3344814 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID D5W6F8
Locus tag BC1002_RS15210 Protein ID WP_013090887.1
Coordinates 3344811..3345221 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BC1002_RS15180 3339792..3340499 - 708 WP_013090880.1 flagellar hook assembly protein FlgD -
BC1002_RS15185 3340510..3340935 - 426 WP_013090881.1 flagellar basal body rod protein FlgC -
BC1002_RS15190 3341064..3341564 - 501 WP_013090882.1 flagellar basal body rod protein FlgB -
BC1002_RS15195 3341781..3343262 + 1482 WP_013090883.1 flagellar basal body P-ring formation protein FlgA -
BC1002_RS15200 3343440..3343799 + 360 WP_013090884.1 flagellar biosynthesis anti-sigma factor FlgM -
BC1002_RS15205 3343894..3344340 + 447 WP_013090885.1 flagellar protein FlgN -
BC1002_RS36300 3344632..3344814 + 183 WP_013090886.1 type II toxin-antitoxin system HicA family toxin Toxin
BC1002_RS15210 3344811..3345221 + 411 WP_013090887.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BC1002_RS15215 3345316..3346050 - 735 WP_013090888.1 RNA polymerase sigma factor FliA -
BC1002_RS15220 3346081..3346950 - 870 WP_013090889.1 AAA family ATPase -
BC1002_RS15225 3346943..3348931 - 1989 WP_013090890.1 flagellar biosynthesis protein FlhF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-129)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6527.65 Da        Isoelectric Point: 11.8222

>T24733 WP_013090886.1 NC_014117:3344632-3344814 [Paraburkholderia atlantica]
MNSAEVVKLIQANGWQLVRIAGSHHHFRHAGKRGLVTVPHPKKDLPAGTLNSILKQAGLK

Download         Length: 183 bp

>T24733 NC_014117:3344632-3344814 [Paraburkholderia atlantica]
ATGAACAGTGCCGAGGTCGTCAAACTGATTCAAGCAAATGGCTGGCAGCTCGTCCGCATAGCGGGCAGTCACCATCATTT
CAGGCACGCGGGAAAACGGGGGCTTGTCACCGTTCCCCACCCGAAAAAAGATCTGCCAGCCGGCACCCTGAACAGCATTC
TGAAACAGGCGGGGCTCAAATGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14893.95 Da        Isoelectric Point: 4.5280

>AT24733 WP_013090887.1 NC_014117:3344811-3345221 [Paraburkholderia atlantica]
MKHLIFPIAIEPGDNTHAFGVVVPDIPGCYSAGDTLEQAYVNAKEAIESHLETLLDEGLPLPEPLTLGEHRRNPEFEGFT
WGFVTTRNIPALKKAVRINISLPEVLVQEIDAYAQARGMSRSAFLALAAEHEMADA

Download         Length: 411 bp

>AT24733 NC_014117:3344811-3345221 [Paraburkholderia atlantica]
ATGAAGCATCTGATCTTTCCGATCGCCATCGAACCGGGGGACAACACGCACGCGTTCGGCGTCGTGGTGCCCGATATCCC
GGGCTGCTACTCCGCGGGCGACACGCTCGAACAAGCGTATGTGAACGCGAAAGAGGCGATCGAATCGCATCTCGAAACCT
TGCTCGACGAAGGGTTGCCGCTGCCCGAGCCGCTCACGCTCGGCGAGCATCGGCGCAATCCCGAGTTCGAGGGGTTCACA
TGGGGTTTCGTGACAACGCGCAATATTCCGGCGTTGAAGAAGGCCGTTCGCATCAATATCTCGCTGCCCGAGGTGCTGGT
GCAGGAGATCGACGCGTATGCTCAGGCGCGCGGCATGTCGCGCTCGGCGTTTCTCGCGCTCGCCGCCGAGCATGAGATGG
CGGACGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H1DD87

Antitoxin

Source ID Structure
AlphaFold DB D5W6F8

References