Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1470321..1470946 Replicon chromosome
Accession NZ_CP098234
Organism Escherichia coli strain ZYB39

Toxin (Protein)


Gene name vapC Uniprot ID A0A2J1DF47
Locus tag KFZ69_RS07115 Protein ID WP_000911331.1
Coordinates 1470548..1470946 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag KFZ69_RS07110 Protein ID WP_000450524.1
Coordinates 1470321..1470548 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ69_RS07085 (1466124) 1466124..1466594 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
KFZ69_RS07090 (1466594) 1466594..1467166 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
KFZ69_RS07095 (1467312) 1467312..1468190 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
KFZ69_RS07100 (1468207) 1468207..1469241 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
KFZ69_RS07105 (1469454) 1469454..1470167 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
KFZ69_RS07110 (1470321) 1470321..1470548 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
KFZ69_RS07115 (1470548) 1470548..1470946 + 399 WP_000911331.1 type II toxin-antitoxin system VapC family toxin Toxin
KFZ69_RS07120 (1471093) 1471093..1471956 + 864 WP_001267507.1 neutral zinc metallopeptidase -
KFZ69_RS07125 (1471971) 1471971..1473986 + 2016 WP_001543081.1 tRNA cytosine(34) acetyltransferase TmcA -
KFZ69_RS07130 (1474060) 1474060..1474758 + 699 WP_000679812.1 esterase -
KFZ69_RS07135 (1474868) 1474868..1475068 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14862.19 Da        Isoelectric Point: 9.2216

>T247324 WP_000911331.1 NZ_CP098234:1470548-1470946 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLVELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT247324 WP_000450524.1 NZ_CP098234:1470321-1470548 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J1DF47

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References