Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 30087..31710 Replicon plasmid unnamed1
Accession NZ_CP098232
Organism Escherichia coli strain XJ34

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag KFZ60_RS23740 Protein ID WP_106474238.1
Coordinates 30087..31412 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag KFZ60_RS23745 Protein ID WP_024136327.1
Coordinates 31417..31710 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ60_RS23710 (KFZ60_23625) 26757..27056 - 300 WP_001572440.1 hypothetical protein -
KFZ60_RS23715 (KFZ60_23630) 27111..27347 - 237 Protein_33 type I restriction-modification system subunit M N-terminal domain-containing protein -
KFZ60_RS23720 (KFZ60_23635) 27801..28226 - 426 WP_001043843.1 hypothetical protein -
KFZ60_RS23725 (KFZ60_23640) 28480..29295 - 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
KFZ60_RS23730 (KFZ60_23645) 29308..29718 - 411 WP_000985911.1 hypothetical protein -
KFZ60_RS23735 (KFZ60_23650) 29820..30026 - 207 WP_000134171.1 hypothetical protein -
KFZ60_RS23740 (KFZ60_23655) 30087..31412 - 1326 WP_106474238.1 type II toxin-antitoxin system HipA family toxin Toxin
KFZ60_RS23745 (KFZ60_23660) 31417..31710 - 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
KFZ60_RS23750 (KFZ60_23665) 32314..32706 - 393 WP_000341066.1 hypothetical protein -
KFZ60_RS23755 (KFZ60_23670) 33079..33420 + 342 WP_001151575.1 hypothetical protein -
KFZ60_RS23760 (KFZ60_23675) 33512..33703 + 192 WP_000398480.1 hypothetical protein -
KFZ60_RS23765 (KFZ60_23680) 33753..34034 + 282 WP_000077926.1 hypothetical protein -
KFZ60_RS23770 34375..34506 - 132 WP_000374059.1 hypothetical protein -
KFZ60_RS23775 (KFZ60_23685) 34597..35838 - 1242 WP_001053338.1 VWA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(A) / blaCTX-M-65 / dfrA14 / ant(3'')-Ia / blaOXA-10 / cmlA1 / ARR-3 / qnrS1 / floR - 1..185577 185577


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(155-404)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50248.21 Da        Isoelectric Point: 6.3505

>T247312 WP_106474238.1 NZ_CP098232:c31412-30087 [Escherichia coli]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHQDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT247312 WP_024136327.1 NZ_CP098232:c31710-31417 [Escherichia coli]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References