Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4356516..4357013 Replicon chromosome
Accession NZ_CP098231
Organism Escherichia coli strain XJ34

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag KFZ60_RS21075 Protein ID WP_001173343.1
Coordinates 4356516..4356689 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag KFZ60_RS21080 Protein ID WP_000398619.1
Coordinates 4356717..4357013 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ60_RS21065 (4353186) 4353186..4354643 + 1458 WP_088375761.1 dipeptide/tripeptide permease DtpC -
KFZ60_RS21070 (4354880) 4354880..4356397 + 1518 WP_001295074.1 lysine--tRNA ligase -
KFZ60_RS21075 (4356516) 4356516..4356689 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
KFZ60_RS21080 (4356717) 4356717..4357013 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
KFZ60_RS21085 (4357240) 4357240..4357512 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
KFZ60_RS21090 (4357524) 4357524..4357754 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
KFZ60_RS21095 (4357935) 4357935..4359566 + 1632 WP_088375762.1 sensor histidine kinase -
KFZ60_RS21100 (4359563) 4359563..4360282 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T247311 WP_001173343.1 NZ_CP098231:c4356689-4356516 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT247311 WP_000398619.1 NZ_CP098231:c4357013-4356717 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References